Results 1 to 10 of about 50,163 (289)

Synchronization Phenomena in Nephron-Nephron Interaction [PDF]

Chaos: An Interdisciplinary Journal of Nonlinear Science, 2001
Experimental data for tubular pressure oscillations in rat kidneys are analyzed in order to examine the different types of synchronization that can arise between neighboring functional units. For rats with normal blood pressure, the individual unit (the nephron) typically exhibits regular oscillations in its tubular pressure and flow variations.
Holstein-Rathlou, N.-H., Mosekilde, Erik, Sosnovtseva, Olga, Yip, K.-P.   +3 more
core   +7 more sources

Nephron and Podocyte Metrics in Adolescents With a History of Low Birth Weight: A Three-Case Report [PDF]

Kidney Medicine
Low birth weight (LBW), which is indicative of impaired fetal growth, is associated with the development of both nephrons and podocytes, increasing the risk of kidney disease later in life. However, the clinical evidence remains limited.
Yuya Yamaguchi, Takaya Sasaki, Kotaro Haruhara, Takeshi Tosaki, Daisuke Nakashima, Yu Honda, Shinya Yokote, Nobuo Tsuboi, Takashi Yokoo   +8 more
doaj   +2 more sources

Stem cells derived from neonatal mouse kidney generate functional proximal tubule-like cells and integrate into developing nephrons in vitro.

PLoS ONE, 2013
We have recently shown that kidney-derived stem cells (KSCs) isolated from the mouse newborn kidney differentiate into a range of kidney-specific cell types.
Egon Ranghini, Cristina Fuente Mora, David Edgar, Simon E Kenny, Patricia Murray, Bettina Wilm   +5 more
doaj   +2 more sources

Estimating Number of Nephrons in Living Pediatric Patients Using Nephrectomy Specimens [PDF]

Kidney International Reports
Introduction: The number of nephrons is a critical determinant of renal health, because chronic kidney disease often results from a reduction in functional nephrons.
Haruhide Sakaguchi, Daishi Hirano, Yuhei Kawakami, Ai Tokunaga, Naoto Nishizaki, Amane Endo, Hiroki Miyano, Yuki Yuza, Saeko Hatanaka, Takaya Sasaki, Go Kanzaki, Nobuo Tsuboi, Kimihiko Oishi   +12 more
doaj   +2 more sources

Somites are a source of nephron progenitors in zebrafish [PDF]

Nature Communications
For over a century it has been believed that the vertebrate kidney arises exclusively from the intermediate mesoderm. Here, we overturn this paradigm by demonstrating that some nephrons, the functional units of the kidney, originate from the somites ...
Zhenzhen Peng, Thitinee Vanichapol, Phong Dang Nguyen, Hao-Han George Chang, Katrinka M. Kocha, Lori L. O’Brien, Peter D. Currie, Peng Huang, Alan J. Davidson   +8 more
doaj   +2 more sources

Axial nephron fate switching demonstrates a plastic system tunable on demand [PDF]

Nature Communications
The human nephron is a highly patterned tubular structure that develops specialized cells to regulate bodily fluid homeostasis, blood pressure, and urine secretion throughout life. Approximately 1 million nephrons form in each kidney during embryonic and
MaryAnne A. Achieng, Jack Schnell, Connor C. Fausto, Réka L. Csipán, Kari Koppitch, Matthew E. Thornton, Brendan H. Grubbs, Nils O. Lindström   +7 more
doaj   +2 more sources

Preliminary Outcomes of NephSIM Nephrons: A Virtual Mentorship Program to Foster Interest in Nephrology [PDF]

Kidney Medicine
Background: Despite concerted efforts by the nephrology community to increase the quality of nephrology education via a plethora of free open access medical education tools and efforts by national nephrology societies, interest in nephrology has mostly ...
Samira S. Farouk, Matthew A. Sparks, Jessica Joseph   +2 more
doaj   +2 more sources

Nephrons, podocytes and chronic kidney disease: Strategic antihypertensive therapy for renoprotection

Hypertension Research, 2022
Chronic kidney disease (CKD) is one of the strongest risk factors for hypertension, and hypertension can exacerbate the progression of CKD. Thus, the management of CKD and antihypertensive therapy are inextricably linked.
Kotaro Haruhara, G. Kanzaki, N. Tsuboi
semanticscholar   +1 more source

Interacting information streams on the nephron arterial network

Frontiers in Network Physiology, 2023
Blood flow and glomerular filtration in the kidney are regulated by two mechanisms acting on the afferent arteriole of each nephron. The two mechanisms operate as limit cycle oscillators, each responding to a different signal.
Donald J. Marsh, Anthony S. Wexler, Niels-Henrik Holstein-Rathlou   +2 more
doaj   +1 more source

Sex-Differences in Solute Transport Along the Nephrons: Effects of Na+ Transport Inhibition.

AJP - Renal Physiology, 2020
Each day approximately 1.7kg of NaCl and 180L of water are reabsorbed by nephron segments in humans, with urinary excretion fine-tuned to meet homeostatic requirements. These tasks are coordinated by a spectrum of renal Na+ transporters. The goal of this
Rui Hu, A. McDonough, A. Layton
semanticscholar   +1 more source