Results 151 to 160 of about 50,163 (289)

TIMP2 promotes AKI‐CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β‐catenin signalling

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. TIMP2 is upregulated in injured renal tubules and promotes maladaptive repair and cell senescence. 2. Genetic deletion of TIMP2 in tubular epithelial cells attenuates renal fibrosis and improves mitochondrial function. 3. TIMP2 activates Wnt/β‐catenin signalling by binding to LRP6 via an MMP‐independent mechanism.
Dongxue Xu, Haichuan Yu, Jingjing Pang, Xiaoyu Zhang, Jun Jiang, Yiming Li, Zhiyong Peng   +6 more
wiley   +1 more source

Generation of Mice Harboring Bicc1 Conditional Null Alleles

genesis, Volume 64, Issue 1, February 2026.
ABSTRACT Bicaudal C1 (Bicc1) encodes an RNA‐binding protein critical for many organ development and epithelial tissue homeostasis. Bicc1 null mutations have been shown to lead to the development of polycystic kidney disease (PKD) and death at an early prenatal stage.
Chia‐Feng Liu, Steven Leon, Isabella Herrig, Oliver Wessely, W. H. Wilson Tang   +4 more
wiley   +1 more source

Acute Toxicity and Genotoxicity of cMoL, a Lectin From Moringa oleifera Seeds With Antifungal Activity Against Cryptococcus Strains

Journal of Applied Toxicology, Volume 46, Issue 2, Page 682-696, February 2026.
ABSTRACT Coagulant Moringa oleifera lectin (cMoL) is one of the compounds involved in the application of M. oleifera seeds for traditional water treatment methods. The present study highlights the new biotechnological potential of cMoL lectin as an antifungal agent against Cryptococcus neoformans B3501 and H99 and Cryptococcus gattii R265 strains ...
Matheus Cavalcanti de Barros, Sávia Soraia Santana da Silva, Eduarda Pinto Gagliano, Alícia Natalie Silva dos Santos, Leydianne Leite de Siqueira Patriota, Gustavo Ramos Salles Ferreira, Pollyanna Michelle da Silva, Simone da Paz Leôncio Alves, Julliano Matheus de Lima Maux, Jacinto da Costa Silva Neto, Fernanda Rafaelly Nascimento de Santana, Fabiana Aparecida Cavalcante Silva, Marilene Henning Vainstein, Luana Cassandra Breitenbach Barroso Coelho, Thâmarah de Albuquerque Lima, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva   +16 more
wiley   +1 more source

Cyclosporine and its metabolites in mother and baby [PDF]

, 1988
Burckart, GJ, Caritis, SN, Koneru, B, Paul Wang, CC, Starzl, TE, Venkataramanan, R   +5 more
core   +1 more source

Applications of Multifunctional Hydrogel in Tissue Engineering and Regenerative Medicine

MedComm, Volume 7, Issue 2, February 2026.
Schematic illustration showing multifunctional hydrogels in the application of tissue engineering and regenerative medicine. ABSTRACT Hydrogels, with excellent hydrophilicity and high‐water content, have emerged as highly versatile biomaterials for tissue engineering and regenerative medicine.
Jieran Lyu, Xuemiao Liu, Qiqi Yang, Yuchang Zhang, Xing Wang   +4 more
wiley   +1 more source

Modeling the Effects of Multiple Myeloma on Kidney Function

, 2018
Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis.
Ayati, Bruce P., Holstein, Sarah A., Walk, Julia C.   +2 more
core  

Fibroblast‐derived neuropilin 1 alleviates renal fibrosis progression

The Journal of Pathology, Volume 268, Issue 2, Page 127-134, February 2026.
Abstract Chronic kidney disease (CKD) is a major global health challenge affecting over 10% of the adult population. A hallmark of CKD progression is the transdifferentiation of kidney fibroblasts into extracellular matrix‐producing myofibroblasts, a key mechanism involved in the decline of kidney function and the development of kidney failure ...
Yunzhu Shen, Sandrine Placier, Liliane Louedec, Perrine Frère, Sophie Vandermeersch, Stefanny Figueroa, Hélène François, Christos E Chadjichristos, Camille Cohen, Christos Chatziantoniou, Amélie Calmont   +10 more
wiley   +1 more source

Gclc as a Marker for Injured Distal Nephron in Ischemia-Reperfusion Induced Acute Kidney Injury

Journal of Inflammation Research
Yinzheng Li,1 Shulin Ma,1 Zheng Wang,1 Mengxia Shi,1 Rui Zeng,1– 4,* Ying Yao1,5,* 1Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2Key ...
Li Y, Ma S, Wang Z, Shi M, Zeng R, Yao Y
doaj  

An improved kidney dissociation and reaggregation culture system results in nephrons arranged organotypically around a single collecting duct system

Organogenesis, 2011
Veronika Ganeva, Mathieu Unbekandt, J. Davies   +2 more
semanticscholar   +1 more source

Circadian Reprogramming of Protein Homeostasis and Glycolipid Metabolism in Diabetic Nephropathy

FASEB BioAdvances, Volume 8, Issue 2, February 2026.
Using time‐series transcriptomic profiling of diabetic mouse kidneys, our study reveals substantial circadian disruption in diabetic nephropathy, with significant impacts on protein homeostasis and glycolipid metabolism. Furthermore, our findings highlight the potential influence of circadian system dysregulation on the disorder of fatty acid ...
Xiao‐Qian Li, Lei Cheng, Tian‐Fen Chen, Yi‐Nuo Ma, Lu‐Yao Wang, Xiao‐Hui Li, Ting‐Yu Fu, Jing Xiao, Zhan‐Zheng Zhao   +8 more
wiley   +1 more source