Results 161 to 170 of about 50,163 (289)

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons.

Kidney International, 2009
T. Kuwabara, K. Mori, M. Mukoyama, M. Kasahara, H. Yokoi, Yoko Saito, T. Yoshioka, Y. Ogawa, Hirotaka Imamaki, T. Kusakabe, K. Ebihara, M. Omata, N. Satoh, A. Sugawara, J. Barasch, K. Nakao   +15 more
semanticscholar   +1 more source

Dual Kidney Transplantation Offers Prolonged Graft Survival

Clinical Transplantation, Volume 40, Issue 2, February 2026.
ABSTRACT Introduction Dual kidney transplantation (DKT), an uncommonly performed procedure, provides a unique opportunity to transplant nonstandard kidneys that might otherwise not be utilized. We compared perioperative and five‐year posttransplant outcomes between DKT, and single kidney transplants (SKT) performed at our institution.
Ekaterina Fedorova, Sofia Nehring Firmino, David Foley, Jacqueline Garonzik‐Wang, Dixon Kaufman, Jon Odorico, David Aufhauser, Nikole A. Neidlinger, Carrie Thiessen, Jennifer Philip, Kelly M. Collins, Josh Mezrich, David Al‐Adra, Didier Mandelbrot, Brad C. Astor, Sandesh Parajuli   +15 more
wiley   +1 more source

CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression

The FEBS Journal, Volume 293, Issue 3, Page 709-728, February 2026.
CLEC18A is a previously poorly characterized C‐type lectin. We mapped the expression of CLEC18A to the proximal tubule of the kidney and found CLEC18A to interact with sulfated glycosaminoglycans on proteoglycans. Furthermore, we found that CLEC18A plays an important role in hindering the progression of clear cell renal cell carcinomas in humans and in
Gustav Jonsson, Maura Hofmann, Stefan Mereiter, Lauren Hartley‐Tassell, Masahiro Onji, Irma Sakic, Tiago Oliveira, David Hoffmann, Maria Novatchkova, Alexander Schleiffer, Josef M. Penninger   +10 more
wiley   +1 more source

Has the time come to change the treatment criteria for patients with chronic kidney disease? The "hypofiltering nephron" hypothesis. [PDF]

Front Nephrol
Romano G, Ferraccioli G, Colussi G.
europepmc   +1 more source

FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons

Development, 2005
U. Grieshammer, C. Cebrián, R. Ilagan, E. Meyers, D. Herzlinger, G. Martin   +5 more
semanticscholar   +1 more source

Principles for Optimal Drug Selection in IgA Nephropathy—Time for Integrating Pathogenesis and Clinical Markers to Guide Therapy

Nephrology, Volume 31, Issue 2, February 2026.
ABSTRACT IgA nephropathy is a progressive glomerular disease with a variable clinical course and a substantial risk of progression to end‐stage kidney failure. While proteinuria has long been the central therapeutic target, insights into disease pathogenesis indicate that haematuria should also guide treatment decisions. Based on the pathophysiology of
Yusuke Suzuki
wiley   +1 more source

The Kidney from Prenatal to Adult Life: Perinatal Programming and Reduction of Number of Nephrons during Development

American Journal of Nephrology, 2009
M. Puddu, V. Fanos, F. Podda, M. Zaffanello   +3 more
semanticscholar   +1 more source

Hypertension and age‐related focal global glomerulosclerosis are associated with biomarkers for cellular senescence

Physiological Reports, Volume 14, Issue 3, February 2026.
Abstract Arterionephrosclerosis is characterized by focal global glomerulosclerosis (FGGS), which is a constant feature of aging and hypertension. FGGS begins as normal‐appearing glomeruli that undergo tuft contraction (TC) and progress to global glomerulosclerosis (GGS).
Michael D. Hughson, Alaa A. Ali, Yusuke Okabayashi, Victor G. Puelles, John F. Bertram   +4 more
wiley   +1 more source

Maternal nutrition can rapidly rescue a nephron deficit in low birthweight offspring. [PDF]

NPJ Metab Health Dis
Cullen-McEwen LA, Gazzard SE, Gonçalves G, Rose AJ, Eliades J, de Zoysa N, Moreau JLM, Hayatudin R, Solon-Biet SM, Wu Y, Mathangasinghe Y, Simpson SJ, Combes AN, Bertram JF.   +13 more
europepmc   +1 more source