Results 41 to 50 of about 50,163 (289)

Centrosome amplification disrupts renal development and causes cystogenesis [PDF]

, 2018
International ...
Amanda Knoten, Arquint, Astrinidis, Battini, Bettencourt-Dias, Bhaskar, Boehlke, Boletta, Brito, Brown, Burtey, Chang-Panesso, Chen, Chi, Coelho, Cosenza, Davenport, Dere, Distefano, Fisher, Ganem, Godinho, Godinho, Godinho, Goto, Habedanck, Hartman, Hendry, Hoshi, Jain, Jain, Janssen, Jinzhi Wang, Jonassen, Keefe Davis, Kobayashi, Krämer, Kulukian, Kyuhwan Shim, Lai Kuan Dionne, Levine, Lin, Ma, Mahjoub, Majumdar, Marthiens, Marthiens, Masato Hoshi, Masyuk, Moe R. Mahjoub, Mugford, Mundlos, Nano, Nigg, Nigg, Ogden, Patel, Quintyne, Renata Basto, Roselli, Saifudeen, Saifudeen, Sanjay Jain, Schmidt-Ott, Serçin, Shao, Sharma, Shillingford, Silkworth, Sillibourne, Simons, Srivastava, Takakura, Tammachote, Tao Cheng, Veronique Marthiens, Vitre, Werner, Yoder, Zhao   +79 more
core   +8 more sources

The number of nephrons in different glomerular diseases [PDF]

PeerJ, 2019
Background The total number of nephrons has been measured mainly from post-mortem studies and only in selected populations. Data from living subjects are scanty, and direct comparisons among different glomerular diseases are lacking.
Davide Viggiano, Michelangelo Nigro, Francesco Sessa, Graziano Vignolini, Riccardo Campi, Sergio Serni, Rosa Maria Pollastro, Gianfranco Vallone, Giuseppe Gigliotti, Giovambattista Capasso   +9 more
doaj   +2 more sources

Low Birth Weight due to Intrauterine Growth Restriction and/or Preterm Birth: Effects on Nephron Number and Long-Term Renal Health

International Journal of Nephrology, 2012
Epidemiological studies have clearly demonstrated a strong association between low birth weight and long-term renal disease. A potential mediator of this long-term risk is a reduction in nephron endowment in the low birth weight infant at the beginning ...
Vladislava Zohdi, Megan R. Sutherland, Kyungjoon Lim, Lina Gubhaju, Monika A. Zimanyi, M. Jane Black   +5 more
doaj   +1 more source

Nephron Patterning: Lessons from Xenopus, Zebrafish, and Mouse Studies

Cells, 2015
The nephron is the basic structural and functional unit of the vertebrate kidney. To ensure kidney functions, the nephrons possess a highly segmental organization where each segment is specialized for the secretion and reabsorption of particular solutes.
Audrey Desgrange, Silvia Cereghini
doaj   +1 more source

The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros. [PDF]

PLoS Genetics, 2007
Kidney function depends on the nephron, which comprises a blood filter, a tubule that is subdivided into functionally distinct segments, and a collecting duct. How these regions arise during development is poorly understood.
Rebecca A Wingert, Rori Selleck, Jing Yu, Huai-Dong Song, Zhu Chen, Anhua Song, Yi Zhou, Bernard Thisse, Christine Thisse, Andrew P McMahon, Alan J Davidson   +10 more
doaj   +1 more source

Neonatal high protein intake enhances neonatal growth without significant adverse renal effects in spontaneous IUGR piglets. [PDF]

, 2017
In humans, early high protein (HP) intake has been recommended to prevent postnatal growth restriction and complications of intrauterine growth restriction (IUGR).
Borel, P., Boubred, F., Boudry, G., Buffat, C., Daniel, L., Jamin, A., Le Huëron-Luron, I., Simeoni, U.   +7 more
core   +3 more sources

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, EarlyView.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

An organ-derived extracellular matrix triggers in situ kidney regeneration in a preclinical model

npj Regenerative Medicine, 2022
It has not been considered that nephrons regenerate in adult mammals. We present that an organ-derived extracellular matrix in situ induces nephron regeneration in a preclinical model.
Kazuki Tajima, Hiroshi Yagi, Toshinori Morisaku, Kotaro Nishi, Hiroko Kushige, Hideaki Kojima, Hisanobu Higashi, Kohei Kuroda, Minoru Kitago, Shungo Adachi, Tohru Natsume, Kumiko Nishimura, Mototsugu Oya, Yuko Kitagawa   +13 more
doaj   +1 more source

Recent advances in the modelling of renal function [PDF]

, 1993
Differential equation models have become an indispensable tool in the effort towards a complete understanding of hypertonic urine formation. Recent advances in this field include the treatment of a kidney model as an inverse prob lern, the modelling of ...
Lory, Peter
core  

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source