Results 51 to 60 of about 50,163 (289)

Optimizing Nephron Performance: The Old, the New, and the New–Old Diuretic Therapies

Biomedicines
Pharmacological influence on nephron function has modified the clinical course of hypertension, heart failure, and chronic kidney disease. (CKD). This is a review of the efficacy of old diuretics and the incremental efficacy of new diuretics in managing ...
Flavio D. Fuchs, Guilherme S. Procianoy, Leonardo G. Bottino, Sandra C. Fuchs, Paul K. Whelton   +4 more
doaj   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Notch Signaling in Kidney Development, Maintenance, and Disease

Biomolecules, 2019
Kidney development involves formation of nephrons intricately aligned with the vasculature and connected to a branched network of collecting ducts.
Malini Mukherjee, Eric Fogarty, Madhusudhana Janga, Kameswaran Surendran   +3 more
doaj   +1 more source

LIM kinase function and renal growth: potential role for LIM kinases in fetal programming of kidney development [PDF]

, 2017
Aims Maternal dietary restriction during pregnancy impairs nephron development and results in offspring with fewer nephrons. Cell turnover in the early developing kidney is altered by exposure to maternal dietary restriction and may be regulated by ...
Alexander J. Sparrow, Arber, Barak, Barker, Bravo-Cordero, Brenner, Carroll, Combes, Dawe, Dressler, Dylan Sweetman, Ghosh, Gilbert, Grieshammer, Hales, Heng, Hoppe, Kobayashi, Kobayashi, Kuure, Langley-Evans, Langley-Evans, Lindstrom, Lloyd, Luyckx, Mackenzie, Merlet-Benichou, Moritz, Mugford, Perantoni, Petrilli, Ritchey, Ross-Macdonald, Schulz, Simon J.M. Welham, Stark, Sumi, Swali, Tarry-Adkins, Toshima, Toshima, Welham, Welham, Welham, White, Yang, Zeman   +46 more
core   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Investigating the Effect of Coenzyme Q10 Supplementation on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Chemotherapy: A Randomized Clinical Trial

Advanced Biomedical Research
Background: Coenzyme Q10 (CoQ10) is a powerful antioxidant and the main cause of kidney problems caused by cisplatin consumption is due to the low power of antioxidants.
Ruhollah Masoumi, Parisa Javadian, Ali Ahmadi, Mehrdad Sepehrni   +3 more
doaj   +1 more source

Determining cellular and biochemical function of a novel adhesion molecule in kidneys. [PDF]

, 2016
Acute kidney injury is an abrupt loss of kidney function that develops in short time with limited effective treatments other than kidney transplantation. We have identified TMIGD1 (Transmembrane immuno- globulin domain 1) as a novel receptor expressed in
Arafa, Emad
core   +1 more source

Renal pericytes: regulators of medullary blood flow [PDF]

, 2012
Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli.
Agmon Y., Beach R.E., Biondi M., Burnstock G., Casellas D., Cohen H.J., Edwards R.M., Guan Z., Harrison‐Bernard L.M., Harrison‐Bernard L.M., Jamison R.L., Kreisberg M.S., Kriz W., Larson T.S., Lazarowski E.R., Lerman L.O., Majid D.S., Pallone T.L., Rouget C., Seldin D.W., Stern M.D., Strick D.M., Takenaka T., Takezawa K., Turner M.R., Unwin R.J., Yamagishi S., Yang S.   +27 more
core   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Branching morphogenesis of the urinary collecting system in the human embryonic metanephros. [PDF]

PLoS ONE, 2018
An elaborate system of ducts collects urine from all nephrons, and this structure is known as the urinary collecting system (UCS). This study focused on how the UCS is formed during human embryogenesis. Fifty human embryos between the Carnegie stage (CS)
Hana Ishiyama, Aoi Ishikawa, Haruka Kitazawa, Sena Fujii, Jun Matsubayashi, Shigehito Yamada, Tetsuya Takakuwa   +6 more
doaj   +1 more source