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Pediatrics In Review, 2022
Nephrotic syndrome (NS) encompasses a variety of disease processes leading to heavy proteinuria and edema. Minimal change disease (MCD) remains the most common primary cause of NS, as well as the most responsive to pharmacologic treatment with often minimal to no chronic kidney disease.
Estefania, Rodriguez-Ballestas +1 more
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Nephrotic syndrome (NS) encompasses a variety of disease processes leading to heavy proteinuria and edema. Minimal change disease (MCD) remains the most common primary cause of NS, as well as the most responsive to pharmacologic treatment with often minimal to no chronic kidney disease.
Estefania, Rodriguez-Ballestas +1 more
openaire +2 more sources
Pediatrics in Review, 2015
On the basis of observational studies, the most common cause of nephrotic syndrome in school-aged children is minimal change disease. On the basis of research evidence and consensus, corticosteroids are considered first-line therapy for treatment of nephrotic syndrome.
Tecile Prince, Andolino +1 more
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On the basis of observational studies, the most common cause of nephrotic syndrome in school-aged children is minimal change disease. On the basis of research evidence and consensus, corticosteroids are considered first-line therapy for treatment of nephrotic syndrome.
Tecile Prince, Andolino +1 more
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New England Journal of Medicine, 1998
The nephrotic syndrome is defined by a urinary protein level exceeding 3.5 g per 1.73 m2 of body-surface area per day. At the turn of the century, clinicians distinguished a nephritic syndrome of inflammatory origin and a nephrotic syndrome of presumed degenerative origin.
S R, Orth, E, Ritz
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The nephrotic syndrome is defined by a urinary protein level exceeding 3.5 g per 1.73 m2 of body-surface area per day. At the turn of the century, clinicians distinguished a nephritic syndrome of inflammatory origin and a nephrotic syndrome of presumed degenerative origin.
S R, Orth, E, Ritz
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Primary Care: Clinics in Office Practice, 1979
The nephrotic syndrome appears to be an expression of a number of complex disease processes. The supportive, as well as the definitive, management of the nephrotic syndrome patient requires considerable knowledge of disease pathophysiology, drugs, and drug interactions. Therapy of any degree cannot be undertaken lightly for fear of further compromising
D, Nagar, R L, Wathen
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The nephrotic syndrome appears to be an expression of a number of complex disease processes. The supportive, as well as the definitive, management of the nephrotic syndrome patient requires considerable knowledge of disease pathophysiology, drugs, and drug interactions. Therapy of any degree cannot be undertaken lightly for fear of further compromising
D, Nagar, R L, Wathen
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New England Journal of Medicine, 1958
Diagnosis The diagnosis of the overt form of the nephrotic syndrome is usually a simple matter. When edema is the presenting complaint, the unmistakable laboratory evidences of the nephrotic syndrome will be found. In a few cases edema is not the presenting complaint; in fact, the patient may never have had edema.
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Diagnosis The diagnosis of the overt form of the nephrotic syndrome is usually a simple matter. When edema is the presenting complaint, the unmistakable laboratory evidences of the nephrotic syndrome will be found. In a few cases edema is not the presenting complaint; in fact, the patient may never have had edema.
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New England Journal of Medicine, 1948
THE "nephrotic syndrome" is one of the most striking phenomena of renal disease. The combination of gross edema, hypoproteinemia, hypercholesterolemia, lipidemia and heavy proteinuria, in the absen...
S E, BRADLEY, C J, TYSON
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THE "nephrotic syndrome" is one of the most striking phenomena of renal disease. The combination of gross edema, hypoproteinemia, hypercholesterolemia, lipidemia and heavy proteinuria, in the absen...
S E, BRADLEY, C J, TYSON
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Proteasuria—The impact of active urinary proteases on sodium retention in nephrotic syndrome
Acta Physiologica, 2019Sodium retention and extracellular volume expansion are typical features of patients with nephrotic syndrome. In recent years, from in vitro data, endoluminal activation of the epithelial sodium channel (ENaC) by aberrantly filtered serine proteases has ...
F. Artunc +3 more
semanticscholar +1 more source
Acta Physiologica, 2019
In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active plasmin by tubular urokinase‐type plasminogen activator (uPA) and thought to lead to sodium retention by proteolytic activation of the epithelial sodium channel (ENaC ...
Bernhard N. Bohnert +13 more
semanticscholar +1 more source
In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active plasmin by tubular urokinase‐type plasminogen activator (uPA) and thought to lead to sodium retention by proteolytic activation of the epithelial sodium channel (ENaC ...
Bernhard N. Bohnert +13 more
semanticscholar +1 more source
The Nephrotic Syndrome and Pregnancy
New England Journal of Medicine, 1962THE nephrotic syndrome and pregnancy rarely co- exist. This may be attributed to the relative infrequency of this disease during the childbearing period and to the obstacles to conception afforded by any serious chronic and frequently incapacitating illness. Wegner1 reported 3 cases out of 12,000 deliveries in 1937.
I A, SILBERMAN, D A, ADAMS
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The American Journal of Medicine, 1974
Abstract Systematic pedigree information was obtained from 70 patients with idiopathic nephrotic syndrome; 16 patients were found to have familial nephrotic syndrome including 1 pair of affected monozygotic twins, 5 affected sibling pairs, 2 affected first cousins from a consanguineous family and 2 patients with sporadic cases from consanguineous ...
P I, Bader +3 more
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Abstract Systematic pedigree information was obtained from 70 patients with idiopathic nephrotic syndrome; 16 patients were found to have familial nephrotic syndrome including 1 pair of affected monozygotic twins, 5 affected sibling pairs, 2 affected first cousins from a consanguineous family and 2 patients with sporadic cases from consanguineous ...
P I, Bader +3 more
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