Results 121 to 130 of about 1,020,690 (253)

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza   +12 more
wiley   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Accessory muscle of the flexor digitorum superficialis and its clinical implications

open access: yesRevista Brasileira de Ortopedia
Anatomical variations of the flexor digitorum superficialis (FDS) muscle and tendon unit are frequently reported by anatomists and clinicians. Anatomical muscle variations of the FDS and its tendons may include variations of muscle belly, presence of ...
Edie Benedito Caetano   +3 more
doaj   +1 more source

Management Approach to Isolated Ocular Motor Nerve Palsies

open access: yes
Anatomy: Optic nerve; Oculomotor nerve; Trochlear nerve; Abducens nerve; Pupil. Disease/Diagnosis: Oculomotor nerve diseases; Trochlear nerve diseases; Oculomotor nerve paralysis; Fourth cranial nerve palsy; Abducens nerve diseases; Gradenigo\u27s ...
Alfredo A. Sadun, MD, PhD
core  

Spontaneous compression of the median nerve in the carpal tunnel

open access: yes, 2018
Numbness, tingling and pain in the hands, sometimes associated with weakness and wasting of the small hand-muscles, is a common condition. Many cases of this symptom complex have been diagnosed, depending on the fashion at the time, as cervical rib ...
Keet, M.P., Beyers, J.A.
core  

Pathogenesis and Therapy of Neurovascular Compression Syndromes: An Editorial

open access: yes
Neurovascular compression syndromes (NVC) remains a challenging disorders resulting from the compression of cranial nerves at the transition zone [...
Bartosz Szmyd   +2 more
core   +1 more source

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor   +11 more
wiley   +1 more source

Electrical stimulation decreases neuralgic pain after trigeminal deafferentation [PDF]

open access: yes, 2008
Trigeminal nerve activity mediates head pain after cranial injuries, and also contributes to idiopathic syndromes such as cluster headache and trigeminal neuralgia. Nevertheless, chronic facial pain sometimes develops after lesion of the trigeminal nerve.
Treleaven-Hassard, S., Drummond, P.D.
core  

Peripheral nerve hyperexcitability syndromes

open access: yes, 2015
Peripheral nerve hyperexcitability (PNH) syndromes can be subclassified as primary and secondary. The main primary PNH syndromes are neuromyotonia, cramp-fasciculation syndrome (CFS), and Morvan's syndrome, which cause widespread symptoms and signs ...
Akcay, Halil Ibrahim   +4 more
core   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

open access: yesBMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng   +4 more
wiley   +1 more source

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