Results 71 to 80 of about 1,142,709 (351)

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Nerve Conduction Studies: What an Intensivist should Know?

, 2022
Sai Saran, Abdul Qavi
openalex   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Correlation of the Lower Limb Nerve Conduction Velocity with Height and Leg Length

Korean Journal of Clinical Laboratory Science
Nerve conduction study (NCS) is an essential test for the diagnosis and follow-up of peripheral neuropathy. NCS can objectively quantify peripheral nerve function. NCS is affected by physiological factors such as height, age, body mass index, etc. Hence,
Jae-Hwan SONG, Sung-Hee KIM, Dae-Hyun KIM   +2 more
doaj   +1 more source

Nerve conduction in relation to vibration exposure - a non-positive cohort study

Journal of Occupational Medicine and Toxicology, 2010
Background Peripheral neuropathy is one of the principal clinical disorders in workers with hand-arm vibration syndrome. Electrophysiological studies aimed at defining the nature of the injury have provided conflicting results.
Nilsson Tohr, Lundström Ronnie, Burström Lage, Wallin B Gunnar, Jonsson Andreas, Sandén Helena, Hagberg Mats   +6 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Serial nerve conduction studies of the tail of rhesus monkey ( Macaca mulatta ) and potential implications for interpretation of human neurophysiological studies

Annals of Indian Academy of Neurology, 2007
It is well accepted in clinical medicine that nerve conduction studies are helpful in the diagnosis of diabetic peripheral neuropathy. However, some clinicians utilize serial nerve conduction studies to make inferences regarding the progression of ...
Graham William, Goldstein Richard, Keith Mansfield, Nesathurai Shanker   +3 more
doaj  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Impact of handedness on electromyographic activity of hand muscles and nerve conduction velocity during mobile phone use

Sport TK
This study investigated the impact of handedness on electromyographic (EMG) activity of hand muscles and nerve conduction velocity during smartphone use and compared the effects of left- and right-handedness on hand muscle activation and nerve ...
Karim Sami Elsaharty, Shaimaa Mohamed Hamed Elmarakby, Nevein Nabil Alagamy, Maha G. Ibrahim, Nehad Mohamed Abdelnabi Mousa, Rana Nabil Hussien   +5 more
doaj   +1 more source