Results 271 to 280 of about 596,225 (341)

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
wiley   +1 more source

Cranial nerve injury

European Journal of Vascular and Endovascular Surgery, 1996
openaire   +2 more sources

Evaluation of the Effect of Platelet-Rich Plasma Injection After Recurrent Nerve Injury in Rats. [PDF]

Laryngoscope Investig Otolaryngol
Senturk A, Harmantepe AT, Yordanagil M, Celik B, Budak O, Doganay S, Turan F, Canturk AO, Capoglu R, Mutlu F.   +9 more
europepmc   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Creation of sensory phantom map of hand using VR robotic system: initial case series

Brain and Spine, 2022
D. Dimante, P.W. Snow, M. Sinisi, A. Krumina, I. Logina, R.C.V. Loureiro   +5 more
doaj  

Can Manual Therapy Alter Muscle Stiffness in Patients With Spinal Accessory Nerve Injury? [PDF]

Otolaryngol Head Neck Surg
Simsek F, Naci B, Kilicoglu MB, Alkan Z, Topcuoglu OM, Gormez A, Hafiz G, Okyar AF.   +7 more
europepmc   +1 more source

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

Molecular mechanisms after optic nerve injury: Neurorepair strategies from a transcriptomic perspective. [PDF]

Neural Regen Res
Chen X, Wei M, Li G.
europepmc   +1 more source

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

Ganglioside GT1b prevents selective spinal synapse removal following peripheral nerve injury. [PDF]

EMBO Rep
Lee J, Noh K, Lee S, Kim KH, Chung S, Lim H, Hwang M, Lee JH, Chung WS, Chang S, Lee SJ.   +10 more
europepmc   +1 more source