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Biomaterials, 2021
Delayed injured nerve regeneration remains a clinical problem, partly ascribing to the lack of regulation of regenerative microenvironment, topographical cues, and blood nourishment. Functional electrospun conduits have been established as an efficacious
Xianzhen Dong +8 more
semanticscholar +1 more source
Delayed injured nerve regeneration remains a clinical problem, partly ascribing to the lack of regulation of regenerative microenvironment, topographical cues, and blood nourishment. Functional electrospun conduits have been established as an efficacious
Xianzhen Dong +8 more
semanticscholar +1 more source
Annual Review of Neuroscience, 1990
Schwann cell basal laminae were demonstrated to serve as efficient conduits for the growth of regenerating axons in frozen nerve grafts, and in in situ freezing experiments. Regenerating axonal sprouts usually emanated from the first node of Ranvier proximal to the site of damage, and grew out along the inner surface of the basal lamina.
J W, Fawcett, R J, Keynes
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Schwann cell basal laminae were demonstrated to serve as efficient conduits for the growth of regenerating axons in frozen nerve grafts, and in in situ freezing experiments. Regenerating axonal sprouts usually emanated from the first node of Ranvier proximal to the site of damage, and grew out along the inner surface of the basal lamina.
J W, Fawcett, R J, Keynes
openaire +4 more sources
Neurosurgery Clinics of North America, 1991
The success of peripheral nerve regeneration is dependent on the survival of axotomized neurons, the efficacy of axonal outgrowth from those neurons, and the specificity of reinnervation of peripheral targets by those neurons. Experimental evidence indicates that following peripheral injury, primary sensory (DRG) neurons and in some cases, motoneurons ...
F J, Liuzzi, B, Tedeschi
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The success of peripheral nerve regeneration is dependent on the survival of axotomized neurons, the efficacy of axonal outgrowth from those neurons, and the specificity of reinnervation of peripheral targets by those neurons. Experimental evidence indicates that following peripheral injury, primary sensory (DRG) neurons and in some cases, motoneurons ...
F J, Liuzzi, B, Tedeschi
openaire +2 more sources
Nerve regeneration and nerve repair
Neurological Research, 2008(2008). Nerve regeneration and nerve repair. Neurological Research: Vol. 30, Nerve Regeneration and Nerve Repair, pp. 997-998.
Rajiv, Midha, Eric L, Zager
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Advances in Materials
Nerve guidance conduits (NGCs) are considered as promising treatment strategy and frontier trend for peripheral nerve regeneration, while their therapeutic outcomes are limited by the lack of controllable drug delivery and available physicochemical cues.
Dongyu Xu +8 more
semanticscholar +1 more source
Nerve guidance conduits (NGCs) are considered as promising treatment strategy and frontier trend for peripheral nerve regeneration, while their therapeutic outcomes are limited by the lack of controllable drug delivery and available physicochemical cues.
Dongyu Xu +8 more
semanticscholar +1 more source
Current Opinion in Neurology, 1995
The regeneration of nerve is a brilliant example of plasticity within the nervous system. Axonal sprouts form within a few hours of nerve injury and grow vigorously over long distances. Nonetheless, recovery from nerve injury, such as that seen after laceration of distal motor-sensory nerve, is often incomplete.
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The regeneration of nerve is a brilliant example of plasticity within the nervous system. Axonal sprouts form within a few hours of nerve injury and grow vigorously over long distances. Nonetheless, recovery from nerve injury, such as that seen after laceration of distal motor-sensory nerve, is often incomplete.
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2005
The nerve chamber model has dominated the experimental study of peripheral nerve (PN) regeneration with animal models as well as in several clinical applications, such as the treatment of paralysis of limbs following severe trauma. The two stumps resulting from nerve transection are inserted inside a tubular chamber made from one of several materials ...
Mei, Zhang, Ioannis V, Yannas
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The nerve chamber model has dominated the experimental study of peripheral nerve (PN) regeneration with animal models as well as in several clinical applications, such as the treatment of paralysis of limbs following severe trauma. The two stumps resulting from nerve transection are inserted inside a tubular chamber made from one of several materials ...
Mei, Zhang, Ioannis V, Yannas
openaire +2 more sources
Experimental Neurology, 2020
Peripheral nerve injuries are common and frequently result in incomplete functional recovery even with optimal surgical treatment. Permanent motor and sensory deficits are associated with significant patient morbidity and socioeconomic burden.
K. Zuo, T. Gordon, K. Chan, G. Borschel
semanticscholar +1 more source
Peripheral nerve injuries are common and frequently result in incomplete functional recovery even with optimal surgical treatment. Permanent motor and sensory deficits are associated with significant patient morbidity and socioeconomic burden.
K. Zuo, T. Gordon, K. Chan, G. Borschel
semanticscholar +1 more source
Neuroscience Research, 1996
Peripheral nerve regeneration comprises the formation of axonal sprouts, their outgrowth as regenerating axons and the reinnervation of original targets. This review focuses on the morphological features of axonal sprouts at the node of Ranvier and their subsequent outgrowth guided by Schwann cells or by Schwann cell basal laminae.
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Peripheral nerve regeneration comprises the formation of axonal sprouts, their outgrowth as regenerating axons and the reinnervation of original targets. This review focuses on the morphological features of axonal sprouts at the node of Ranvier and their subsequent outgrowth guided by Schwann cells or by Schwann cell basal laminae.
openaire +2 more sources
Advanced Functional Materials, 2020
Peripheral nerve injury is a common clinical problem bringing heavy burden to patients, due to its high incidence and unsatisfactory treatment. Nerve guidance conduit (NGC) is a promising scaffold for peripheral nerve repair, and bioactive agents are ...
Xuan Chen +7 more
semanticscholar +1 more source
Peripheral nerve injury is a common clinical problem bringing heavy burden to patients, due to its high incidence and unsatisfactory treatment. Nerve guidance conduit (NGC) is a promising scaffold for peripheral nerve repair, and bioactive agents are ...
Xuan Chen +7 more
semanticscholar +1 more source