Results 101 to 110 of about 19,580,326 (251)

Cornichons: Evolution, AMPA receptor modulation, and emerging roles beyond the nervous system

Brain Disorders
Cornichons are auxiliary proteins that regulate the functions of AMPA receptors (AMPARs), which mediate fast excitatory transmission in the central nervous system.
Pratibha Bharti, Anshul Assaiya, Bhavya K Dawath, Janesh Kumar   +3 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Ploidy and neuron size impact nervous system development and function in Xenopus

Cell Reports
Summary: Neuron size varies significantly over evolution, contributing to diverse nervous systems of variable complexity, while aberrant neuron size is associated with neurodevelopmental and degenerative diseases. How do neuron cell body and neurite size
Xiao Liu, Christine Wan, Sara Aijaz Shah, Rebecca Heald   +3 more
doaj   +1 more source

Essential Clinical Anatomy of the Nervous System [1st Ed.]

, 2015
A clear and succinct presentation of the underlying anatomy of the nervous system, with directly related applications of the anatomy to clinical ...
Rea, Paul
core  

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Diseases of the nervous system /

The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and ...
Sontheimer, Harald,author.
core  

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Parent brain responses to child facial and vocal communication: What different methodologies reveal about parenting cognitions and practices as well as their moderation by parental status, gender, and culture as well as child characteristics

Neuroscience Research
Parenting is constituted of caregiving cognitions and practices, based in evolution and biology as well as culture and context, and lodged in nervous system structure and function. This narrative review first discusses parenting and an orientation toward
Marc H. Bornstein, Amir Gandjbakhche, Thien Nguyen, Gianluca Esposito   +3 more
doaj   +1 more source

Central nervous system parasites

When parasitic infections of the Central Nervous System (CNS) are examined, we encounter quite a lot of parasites. Among protozoans, especially free-living amoebae (such as Naegleria, Acanthamoeba, Balamuthia, and Sappinia) have attracted attention in ...
Aydinli, A.
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source