Results 11 to 20 of about 6,129 (164)

Targeting the TRIM28-EZH2 Protein-Protein Interface With Cysteine-Reactive Covalent Inhibitors: A Computational Blueprint for Cancer Therapy. [PDF]

Chem Biodivers
Graphical overview of the computational strategy employed to disrupt the oncogenic TRIM28EZH2 proteinprotein interaction. The workflow illustrates proteinprotein docking to define the interaction interface, cysteine‐focused covalent virtual screening targeting EZH2 Cys144, covalent docking, molecular dynamics simulations, and MM‐GBSA binding free ...
Kehinde IO, Mzozoyana V, Zamisa SJ, Faya M, Soliman MES.   +4 more
europepmc   +2 more sources

Dissection of GTPase activating proteins reveals functional asymmetry in the COPI coat of budding yeast. [PDF]

, 2019
The Arf GTPase controls formation of the COPI vesicle coat. Recent structural models of COPI revealed the positioning of two Arf1 molecules in contrasting molecular environments.
Arakel, E., Estrada, A., Huranova, M., Rau, E., Schwappach, B., Spang, A.   +5 more
core   +1 more source

A Chlamydia effector recruits CEP170 to reprogram host microtubule organization [PDF]

, 2015
The obligate intracellular bacterial pathogen Chlamydia trachomatis deploys virulence effectors to subvert host cell functions enabling its replication within a specialized membrane-bound compartment termed an inclusion.
Abdelrahman, Al-Younes, Al-Zeer, Alzhanov, Archuleta, Bannantine, Beatty, Carabeo, Cocchiaro, D'Avino, Delevoye, Dumoux, Eliceiri, Gauliard, Grieshaber, Guarguaglini, Hoare, Hybiske, Jewett, Johnson, Koskela, Kumar, Lane, Leonhardt, Lutter, Maliga, Miroux, Mital, Mital, Nans, Nigg, Peters, Radhakrishman, Richards, Romano, Rzomp, Schmid, Schwan, Scidmore, Smith, Welburn, Wilson, Woodruff   +42 more
core   +3 more sources

An Introduction to Programming for Bioscientists: A Python-based Primer [PDF]

, 2016
Computing has revolutionized the biological sciences over the past several decades, such that virtually all contemporary research in the biosciences utilizes computer programs.
Ekmekci, Berk, McAnany, Charles E., Mura, Cameron   +2 more
core   +6 more sources

Identification and function of long non-coding RNA [PDF]

, 2013
Long non-coding (lnc) RNAs are defined as non-protein coding RNAs distinct from housekeeping RNAs such as tRNAs, rRNAs, and snRNAs, and independent from small RNAs with specific molecular processing machinery such as micro- or piwi-RNAs.
Ernst, Carl, Morton, Cynthia C.
core   +2 more sources

Siglec receptors impact mammalian lifespan by modulating oxidative stress. [PDF]

, 2015
Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number
Fu, Xiaoming, Gagneux, Pascal, Garcia, Javier O, Garcia-Bingman, Andrea, Glass, Christopher K, Hazen, Stanley L, Heyser, Charles, Lin, Hongqiao, Läubli, Heinz, Pearce, Oliver MT, Romanoski, Casey E, Samraj, Annie N, Schwarz, Flavio, Secrest, Patrick, Varki, Ajit, Varki, Nissi, Wang, Xiaoxia   +16 more
core   +1 more source

Stalking influenza by vaccination with pre-fusion headless HA mini-stem. [PDF]

, 2016
Inaccuracies in prediction of circulating viral strain genotypes and the possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine with increased breadth of protection and potential for rapid ...
A Schneemann, AH Ellebedy, C Ganesh, CJ Wei, D Corti, D Sharma, DC Ekiert, DC Ekiert, DG Higgins, DJ DiLillo, DT O’Hagan, F Ferrara, F Krammer, F Krammer, G Bommakanti, G Bommakanti, J Stevens, J Sui, JJ Skehel, JJ Skehel, JR Whittle, MB Mazanec, NJ Temperton, PH Goff, RD de Vries, S Guthe, S Jegaskanda, S Khurana, SA Valkenburg, TJ Wohlbold, U Rathore, VV Mallajosyula, VV Mallajosyula, W Gerhard, Y Huang, Y Wu   +35 more
core   +2 more sources

Induction of cytotoxic T-cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus [PDF]

, 1997
A replication-defective recombinant adenovirus (RAd), RAdCMV-CE1, containing core and E1 genes of hepatitis C virus (HCV) was constructed. RAdCMV-CE1 was able to express core and E1 proteins both in mice and human cells.
Borras-Cuesta, F. (Francisco), Bruña-Romero, O. (Oscar), Grace, K. (Ken), Klarke, B. (Berwyn), Lasarte, J.J. (Juan José), Prieto, J. (Jesús), Wilkinson, G. (Gavin)   +6 more
core   +1 more source

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source