Results 11 to 20 of about 26,946 (162)

Quality Analysis of Raw Material and Products of Goat Bezoar (Houzao), a Mysterious Traditional Medicine. [PDF]

Phytochem Anal
Goat bezoar is a precious imported Chinese Medicine widely used for centuries in pediatric treatments. However, its unclear chemical profile brings challenge for the identification and the establishment of quality standards. In this study, qualitative and quantitative determination methods of goat bezoar chemical profile were well developed and ...
Pun SW, Fung HY, Zhu P, Zhang Z, Hu H, Feng Y, Zhao Z, Li L, Han Q.   +8 more
europepmc   +2 more sources

Evidence for vitellogenin DNA-binding in honey bees. [PDF]

Protein Sci
Abstract DNA‐binding proteins play essential roles in DNA replication, DNA repair, DNA organization, and several aspects of gene regulation. Their well‐studied structures and charge configurations aid in identifying similar functions in other proteins. Vitellogenin (Vg) is a highly conserved protein that is central to egg‐yolk formation in most animal ...
Harwood G, Leipart V, Elsik C, Ng JCF, Drabløs F, Amdam GV.   +5 more
europepmc   +2 more sources

Human Schlafen 14 Cleavage of Short Double-Stranded RNAs Underpins its Antiviral Activity. [PDF]

Adv Sci (Weinh)
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Li M, Sun D, Hao W, Fu H, Zhang Y, Li Z, Qin B, Wang Y, Cui S.   +8 more
europepmc   +2 more sources

Structural versatility that serves the function of the HRD motif in the catalytic loop of protein tyrosine kinase, Src

Protein Science, 2018
Site‐directed mutagenesis is a traditional approach for structure–function analysis of protein tyrosine kinases, and it requires the generation, expression, purification, and analysis of each mutant enzyme.
Yixin Cui, Gongqin Sun
semanticscholar   +1 more source

Phosphorylation Changes SARS-CoV-2 Nucleocapsid Protein's Structural Dynamics and Its Interaction With RNA. [PDF]

Proteins
ABSTRACT The SARS‐CoV‐2 nucleocapsid protein, or N‐protein, is a structural protein that plays an important role in the SARS‐CoV‐2 life cycle. The N‐protein takes part in the regulation of viral RNA replication and drives highly specific packaging of full‐length genomic RNA prior to virion formation.
Loonen S, van Steenis L, Bauer M, Šoštarić N.   +3 more
europepmc   +2 more sources

Why is binding of a divalent metal cation to a structural motif containing four carboxylate residues not accompanied by a conformational change?

Protein Science
We earlier showed that Torpedo californica acetylcholinesterase (AChE) contains a cluster of four conserved aspartates that can strongly bind divalent cations, which we named the 4D motif.
Sofya Lushchekina, Lev Weiner, Y. Ashani, Reeki Emrizal, Mohd Firdaus-Raih, I. Silman, J. L. Sussman   +6 more
semanticscholar   +1 more source

Ab initio folding of a trefoil‐fold motif reveals structural similarity with a β‐propeller blade motif

Protein Science, 2020
Many protein architectures exhibit evidence of internal rotational symmetry postulated to be the result of gene duplication/fusion events involving a primordial polypeptide motif. A common feature of such structures is a domain‐swapped arrangement at the
Connie A. Tenorio, L. Longo, Joseph B Parker, Jihun Lee, M. Blaber   +4 more
semanticscholar   +1 more source

Recycling of Thermoplastics with Machine Learning: A Review

Advanced Functional Materials, EarlyView.
This review shows how machine learning is revolutionizing mechanical, chemical, and biological pathways, overcoming traditional challenges and optimizing sorting, efficiency, and quality. It provides a detailed analysis of effective feature engineering strategies and establishes a forward‐looking research agenda for a truly circular thermoplastic ...
Rodrigo Q. Albuquerque, Florian Stephan, Annalena Pongratz, Christian Brütting, Katharina Krause, Holger Ruckdäschel   +5 more
wiley   +1 more source

Structural motif screening reveals a novel, conserved carbohydrate-binding surface in the pathogenesis-related protein PR-5d

BMC Structural Biology, 2010
BackgroundAromatic amino acids play a critical role in protein-glycan interactions. Clusters of surface aromatic residues and their features may therefore be useful in distinguishing glycan-binding sites as well as predicting novel glycan-binding ...
A. Doxey, Zhenyu Cheng, B. Moffatt, B. McConkey   +3 more
semanticscholar   +1 more source

Snapshots of urea‐induced early structural changes and unfolding of an ankyrin repeat protein at atomic resolution

Protein Science, 2022
Protein folding and unfolding is a complex process, underscored by the many proteotoxic diseases associated with misfolded proteins. Mapping pathways from a native structure to an unfolded protein or vice versa, identifying the intermediates, and ...
M. G. Mukund Sudharsan, Somavally Dalvi, Prasanna Venkatraman   +2 more
semanticscholar   +1 more source