Results 41 to 50 of about 5,716 (123)

Phosphorylation Changes SARS‐CoV‐2 Nucleocapsid Protein's Structural Dynamics and Its Interaction With RNA

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The SARS‐CoV‐2 nucleocapsid protein, or N‐protein, is a structural protein that plays an important role in the SARS‐CoV‐2 life cycle. The N‐protein takes part in the regulation of viral RNA replication and drives highly specific packaging of full‐length genomic RNA prior to virion formation.
Stefan Loonen, Lina van Steenis, Marianne Bauer, Nikolina Šoštarić   +3 more
wiley   +1 more source

Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates. [PDF]

, 2019
Dietary habits have been associated with alterations of the human gut resident microorganisms contributing to obesity, diabetes and cancer1. In Western diets, red meat is a frequently eaten food2, but long-term consumption has been associated with ...
Alisson-Silva, Frederico, Chang, Geoffrey, Chuzel, Léa, Diaz, Sandra L, Ganatra, Mehul B, Huang, Jianbo, Martino, Cameron, Rees, Steven D, Secrest, Patrick, Siegel, Dionicio, Taron, Christopher H, Varki, Ajit, Zaramela, Livia S, Zengler, Karsten, Zuñiga, Cristal   +14 more
core  

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity [PDF]

, 2018
Ubiquitination is initiated by transfer of ubiquitin (Ub) from a ubiquitin-activating enzyme (E1) to a ubiquitin-conjugating enzyme (E2), producing a covalently linked intermediate (E2-Ub)(1). Ubiquitin ligases (E3s) of the 'really interesting new gene' (
A Borodovsky, A Hershko, A Plechanovová, AA Yunus, AF Alpi, Axel Knebel, B Grill, B Stieglitz, B Stieglitz, B Yang, BC Lechtenberg, Daan M. F. van Aalten, DM Wenzel, DS Hewings, E Babetto, G Langer, GN Murshudov, H Dou, HI Wan, J You, JE Brownell, JM Huibregtse, JN Pruneda, K Cadwell, Karim Rafie, Kay Hofmann, KC Pao, KK Dove, Kuan-Chuan Pao, L Conforti, M Scheffner, M Stanley, M Zhen, Mathew Stanley, MJ Niphakis, N Zheng, Nicola T. Wood, P Emsley, Peter D. Mabbitt, PY Wu, R Byrne, Ramasubramanian Sundaramoorthy, RJ Deshaies, S Milde, Satpal Virdee, SC Lovell, SK Olsen, X Wang, X Xiong, Y Shimizu, YO Ali   +50 more
core   +2 more sources

Interparticle Crosslinked Ion‐Responsive Microgels for 3D and 4D (Bio)Printing Applications

Small, EarlyView.
A novel strategy is developed that enables interparticle crosslinking of microgels, eliminating the need for filler hydrogels and preserving essential microscale void spaces to support cell migration and vascularization. These microgels possesses unique, ion‐responsive shrinking behavior primarily by the Hofmeister effect, reversible upon the removal ...
Vaibhav Pal, Deepak Gupta, Suihong Liu, Ilayda Namli, Syed Hasan Askari Rizvi, Yasar Ozer Yilmaz, Logan Haugh, Ethan Michael Gerhard, Ibrahim T. Ozbolat   +8 more
wiley   +1 more source

Characterization and phylogenetic analysis of the chitinase gene from the Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus [PDF]

, 2004
A putative chitinase gene was identified within the fragment EcoRI-K of the Helicoverpa armigera single-nucleocapsid nucleopolyhedrovirus (HearNPV, also called HaSNPIV) genome.
Arif, BM, Chen, XW, Deng, F, Hu, ZH, Hu, ZH, Chinese Acad Sci, Wuhan Inst Virol, Joint Lab Invertebrate Virol, Wuhan 430071, Peoples R China, Jehle, JA, Lauzon, H, Peng, HY, Wang, HL, Wu, D   +9 more
core   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Ecosystem services provided by spiders

Biological Reviews, EarlyView.
ABSTRACT Spiders, ubiquitous and abundant predators in terrestrial ecosystems, often are the subjects of an unjust negative perception. However, these remarkable creatures stand as unsung heroes within our ecosystems, contributing a multitude of ecosystem services critical to human well‐being.
Pedro Cardoso, Stano Pekár, Klaus Birkhofer, Angela Chuang, Caroline Sayuri Fukushima, Eileen A. Hebets, Yann Henaut, Thomas Hesselberg, Jagoba Malumbres‐Olarte, Ondřej Michálek, Radek Michalko, Catherine Scott, Jonas Wolff, Stefano Mammola   +13 more
wiley   +1 more source

Induction of cytotoxic T-cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus [PDF]

, 1997
A replication-defective recombinant adenovirus (RAd), RAdCMV-CE1, containing core and E1 genes of hepatitis C virus (HCV) was constructed. RAdCMV-CE1 was able to express core and E1 proteins both in mice and human cells.
Borras-Cuesta, F. (Francisco), Bruña-Romero, O. (Oscar), Grace, K. (Ken), Klarke, B. (Berwyn), Lasarte, J.J. (Juan José), Prieto, J. (Jesús), Wilkinson, G. (Gavin)   +6 more
core   +1 more source

Tasks and Visual Abstractions for 3D Chromatin Representation

Computer Graphics Forum, EarlyView.
Abstract The spatial organization of chromatin fiber directly influences its function. However, the high visual complexity of chromatin spatial models makes the understanding of the structure extremely challenging. Therefore, genomic researchers still primarily rely on indirect analysis of chromatin through 2D views, missing the advantages that 3D ...
A. Rychlý, J. Byška, B. Kozlíková, K. Furmanová   +3 more
wiley   +1 more source

Siglec receptors impact mammalian lifespan by modulating oxidative stress. [PDF]

, 2015
Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number
Fu, Xiaoming, Gagneux, Pascal, Garcia, Javier O, Garcia-Bingman, Andrea, Glass, Christopher K, Hazen, Stanley L, Heyser, Charles, Lin, Hongqiao, Läubli, Heinz, Pearce, Oliver MT, Romanoski, Casey E, Samraj, Annie N, Schwarz, Flavio, Secrest, Patrick, Varki, Ajit, Varki, Nissi, Wang, Xiaoxia   +16 more
core   +1 more source