Results 41 to 50 of about 26,946 (162)

N‐Amino Peptide–Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies

Advanced NanoBiomed Research, EarlyView.
A neuron‐targeting drug delivery system is developed by incorporating the tau‐specific N‐amino peptide, mxyl‐NAP2, with graphene quantum dots (GQDs) and encapsulating the complex into small extracellular vesicles functionalized with a neuron‐targeting ligand.
Runyao Zhu, Gaeun Kim, Benjamin H. Rajewski, Isaac J. Angera, Juan R. Del Valle, Yichun Wang   +5 more
wiley   +1 more source

CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer

Cancer Communications, EarlyView.
Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang, Guoshu Bi, Xiaolong Huang, Zhijie Xu, Yiwei Huang, Yunyi Bian, Guangyao Shan, Wei Guo, Yuanliang Yan, Qihai Sui, Xiaodong Yang, Zhencong Chen, Tao Lu, Huan Zhang, Qun Wang, Wei Jiang, Cheng Zhan   +16 more
wiley   +1 more source

Microfluidic‐Assisted Evolution of a Robust NAD+‐Dependent Enzyme with Improved Isobutanol Tolerance at Elevated Temperatures

ChemSusChem, EarlyView.
Utilizing the power of the absorbance‐activated droplet sorter, a key enzyme for a cell‐free multienzymatic cascade for sustainable isobutanol biosynthesis is optimized for improved thermostability and isobutanol tolerance required for efficient cascade performance.
Mariko Teshima, Robert Genth, Tenuun Bayaraa, Manuel Döring, Barbara Beer, Gerhard Schenk, Volker Sieber   +6 more
wiley   +1 more source

Liquid Biopsies in Head and Neck Cancers: Recent Developments Across Biofluids, Analytes, and Molecular Features

Head &Neck, EarlyView.
ABSTRACT Background Head and neck cancers (HNCs) are too often diagnosed at advanced stages when outcomes are poor. Additionally, robust tools for the early detection of recurrence remain elusive. These gaps drive interest in so‐called liquid biopsy approaches for HNC detection, prognostication, and surveillance.
Patricia J. Brooks, Scott V. Bratman
wiley   +1 more source

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Chloroplast genome of the critically endangered Ginger Zingiber odoriferum Blume from Java, Indonesia: characterization, comparison, and conservation insights

Nordic Journal of Botany, EarlyView.
Zingiber odoriferum (Zingiberaceae), a critically endangered ginger species endemic to Java, Indonesia, is ecologically vital yet genomically understudied. We present the first complete chloroplast (cp) genome (163 538 bp), revealing a quadripartite structure with a large single‐copy region (88 033 bp), a small single‐copy region (15 885 bp), and a ...
Irfan Martiansyah, Risha Amilia Pratiwi, Muhammad Rifqi Hariri, Mahat Magandhi, Asih Perwita Dewi, Andik Wijayanto   +5 more
wiley   +1 more source

Nectar concentrations of biogenic amines affect bumble bee behavior in a dose‐dependent manner

Oikos, EarlyView.
While foraging, pollinators encounter a wide array of molecules, some of which may influence their internal states and behaviors. Among these, biogenic amines – nitrogenous compounds that serve as essential neuromodulators in animals – have only recently been detected in floral nectar.
Marta Barberis, Daniele Calabrese, David Baracchi, Laura Bortolotti, Flavia Di Cesare, Rosa Ranalli, Laura Zavatta, Massimo Nepi, Marta Galloni, Gherardo Bogo   +9 more
wiley   +1 more source

Comparative Analyses of Four Reference Genomes Reveal Exceptional Diversity and Weak Linked Selection in the Yellow Monkeyflower (Mimulus guttatus) Complex

Molecular Ecology Resources, EarlyView.
ABSTRACT Yellow monkeyflowers (Mimulus guttatus complex, Phrymaceae) are a powerful system for studying ecological adaptation, reproductive variation, and genome evolution. To initiate pan‐genomics in this group, we present four chromosome‐scale assemblies and annotations of accessions spanning a broad evolutionary spectrum: two from a single M ...
John T. Lovell, Rachel Walstead, Amelia Lawrence, Evan Stark‐Dykema, Matthew C. Farnitano, Avril Harder, Tomáš Brůna, Kerrie Barry, David Goodstein, Jerry Jenkins, Anna Lipzen, LoriBeth Boston, Jenell Webber, Mansi Chovatia, Joanne Eichenberger, Jayson Talag, Jane Grimwood, Jeremy Schmutz, John K. Kelly, Andrea L. Sweigart, Lila Fishman, John H. Willis   +21 more
wiley   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Ecosystem services provided by spiders

Biological Reviews, EarlyView.
ABSTRACT Spiders, ubiquitous and abundant predators in terrestrial ecosystems, often are the subjects of an unjust negative perception. However, these remarkable creatures stand as unsung heroes within our ecosystems, contributing a multitude of ecosystem services critical to human well‐being.
Pedro Cardoso, Stano Pekár, Klaus Birkhofer, Angela Chuang, Caroline Sayuri Fukushima, Eileen A. Hebets, Yann Henaut, Thomas Hesselberg, Jagoba Malumbres‐Olarte, Ondřej Michálek, Radek Michalko, Catherine Scott, Jonas Wolff, Stefano Mammola   +13 more
wiley   +1 more source