Results 71 to 80 of about 5,716 (123)
Adaptive plasticity of killifish (Fundulus heteroclitus) embryos: dehydration-stimulated development and differential aquaporin-3 expression [PDF]
, 2009 13 pages, 7 figures, 3 tablesEmbryos of the marine killifish Fundulus heteroclitus are adapted to survive aerially. However, it is unknown if they are able to control development under dehydration conditions.
A Esteban +52 more
core +1 more source
Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets
MedComm, Volume 6, Issue 7, July 2025.Cancer‐associated fibroblasts (CAFs) arise from normal fibroblasts in response to various tumor microenvironmental signals, including cytokines such as TGF‐β and IL‐6, paracrine factors like PDGFs, Notch signaling, extracellular vesicles, as well as aging, inflammation, hypoxia, oxidative stress, and increased extracellular matrix (ECM) stiffness. Upon
Yutao Li +6 more
wiley +1 more source
Molecular Genetics &Genomic Medicine, Volume 13, Issue 7, July 2025.The novel intronic potentially pathogenic mutation in the MBD5 gene results in aberrant splicing of mRNA within the body. The protein transcribed from this abnormal mRNA undergoes changes in its spatial structure, with alterations in the electrostatic potential on the protein surface.
Heng Jiang +6 more
wiley +1 more source
Christian Bohr. Discoverer of Homotropic and Heterotopic Allostery
Acta Physiologica, Volume 241, Issue S734, July 2025.ABSTRACT This essay recounts and revisits the scientific contributions of Christian Bohr, highlighting his pivotal role in discovering allostery about 120 years ago. Bohr's meticulous experimentation led to identifying two distinct forms of allostery: homotropic (single‐ligand) and heterotropic (multi‐ligand), the latter widely recognized as the Bohr ...
Niels Bindslev
wiley +1 more source
Plant Biotechnology Journal, Volume 23, Issue 7, Page 2852-2870, July 2025.Summary Pomegranate is an important perennial fruit tree distributed worldwide. Reference genomes with gaps and limit gene identification controlling important agronomic traits hinder its functional genomics and genetic improvements. Here, we reported a telomere‐to‐telomere (T2T) gap‐free genome assembly of the distinctive cultivar ‘Moshiliu’.
Lina Chen +18 more
wiley +1 more source
Antimicrobial and cytolytic peptides of venomous arthropods [PDF]
, 2018 As a response to invading microorganisms, the innate immune system of arthropods has evolved a complex arrangement of constitutive and inducible antimicrobial peptides that immediately destroy a large variety of pathogens.
Kuhn-Nentwig, L.
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Co-encapsulation of an antigen and CpG oligonucleotides into PLGA microparticles by TROMS technology. [PDF]
, 2008 It seems well established that CpG oligonucleotides Th1 biased adjuvant activity can be improved when closely associated with a variety of antigens in, for example, microparticles.
Espuelas, S. (Socorro) +5 more
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Navigating the Extremes of Biological Datasets for Reliable Structural Inference and Design [PDF]
, 2013 Structural biologists currently confront serious challenges in the effective interpretation of experimental data due to two contradictory situations: a severe lack of structural data for certain classes of proteins, and an incredible abundance of data ...
Hannigan, Brett Thomas
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The early history and emergence of molecular functions and modular scale-free network behavior [PDF]
, 2015 The formation of protein structural domains requires that biochemical functions, defined by conserved amino acid sequence motifs, be embedded into a structural scaffold. Here we trace domain history onto a bipartite network of elementary functional loop (
Aziz, Muhammad Fayez
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