Results 71 to 80 of about 6,138 (148)
ChemBang: Expanding the Chemical Space Around Small Molecules
Molecular Informatics, Volume 45, Issue 5, May 2026.Schematic diagram of the underlying concepts behind ChemBang and the molecular generation process from a seed molecular structure by applying the three main categories of chemical transformations, namely, interchange of small substituents, replacement of ring systems, and scaffold enlargement by additional ring systems.
Diana Montes‐Grajales +3 more
wiley +1 more source
Family‐level specialization in protein domain insertion architectures
Protein Science, Volume 35, Issue 5, May 2026.Abstract Domain insertion creates architectures where one domain interrupts another's sequence. Analysis across 2.7 million classified domains reveals that insertions occur in 20% of multidomain proteins, with 331 families exhibiting consistent architectural roles: 162 function exclusively as hosts, while 169 exclusively serve as inserted modules, such
R. Dustin Schaeffer +4 more
wiley +1 more source
Molecular Ecology Resources, Volume 26, Issue 4, May 2026.ABSTRACT Spiders are renowned for their ecological versatility and silk‐based innovations in materials science, yet marine environments remain virtually uncolonized by this predominantly terrestrial lineage. A striking exception is the obligate intertidal spider genus Desis, whose members have evolved extraordinary physiological and behavioural ...
Fan Li +11 more
wiley +1 more source
Andrology, Volume 14, Issue 4, Page 978-991, May 2026.Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre +5 more
wiley +1 more source
Co-encapsulation of an antigen and CpG oligonucleotides into PLGA microparticles by TROMS technology. [PDF]
, 2008 It seems well established that CpG oligonucleotides Th1 biased adjuvant activity can be improved when closely associated with a variety of antigens in, for example, microparticles.
Espuelas, S. (Socorro) +5 more
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Brain Pathology, Volume 36, Issue 3, May 2026.We report a novel FGFR2::TXLNB fusion in a child with hippocampal PLNTY. This fusion likely drives tumorigenesis via homodimerization and activation of MAPK/PI3K pathways, expanding PLNTY's molecular spectrum and suggesting a potential therapeutic target.
Sha‐Sha Hu +3 more
wiley +1 more source
T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age‐Related Diseases
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT Cardiovascular diseases (CVD) are shaped by a complex interplay with immune mechanisms. In particular, the distinct roles of antigen‐specific T cell mechanisms are emerging as critical determinants across a broad spectrum of conditions, ranging from atherosclerosis, myocardial infarction (MI), heart failure (HF), and myocarditis. Because these
Leon Richter +3 more
wiley +1 more source
Molecular Microbiology, Volume 125, Issue 5, Page 426-441, May 2026.We identify the long‐known virulence factor VirJ as a lysyl‐phosphatidylglycerol (L‐PG) hydrolase. Like the chromosomally encoded virulence factor AcvB, it prevents excessive accumulation of L‐PG in the membrane, thereby maintaining efficient T‐DNA transfer via the Type IV secretion system (T4SS) in Agrobacterium tumefaciens.
Britta Lotz +9 more
wiley +1 more source
S2‐PepAnalyst: A Web Tool for Predicting Plant Small Signalling Peptides
Plant Biotechnology Journal, Volume 24, Issue 5, Page 3244-3260, May 2026.ABSTRACT Small signalling peptides (SSPs) serve as crucial mediators of cell‐to‐cell communication in plants, orchestrating diverse physiological processes from development to stress responses. While recent advances in sequencing technologies have improved genome annotation, the identification of novel SSPs remains challenging due to their small size ...
Kelly L. Vomo‐Donfack +5 more
wiley +1 more source
Metalloids: Semi as Metals yet Full of Antimicrobial Potential
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm +2 more
wiley +1 more source