Results 131 to 140 of about 11,492 (243)

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley, Md. Monirul Islam, Dean J. Aguiar, Zoë Fuchs, Mackenzie Catron, Stephen Morairty, Ying Yuan, Radleigh Santos, Jingguo Hou, Annelies de Kater, George B. Thornton, Angelique Bordey   +11 more
wiley   +1 more source

Collectors, not hoarders: Complex gene structures in Amphidinium carterae revealed through nanopore sequencing. [PDF]

BMC Genomics
Judd M, Baldino A, Wira J, Place AR, Bachvaroff T.   +4 more
europepmc   +1 more source

Stereo‐EEG mapping of visual working memory with task‐related high‐gamma modulations

Epilepsia, EarlyView.
Abstract Objective We describe a safe, informative, and easy‐to‐implement approach for presurgical mapping of visual working memory (VWM) with stereo‐electroencephalography (SEEG). Methods Twenty‐four patients with drug‐resistant epilepsy, 11–23 years of age, performed a single‐probe change detection VWM task, during SEEG monitoring.
Brian Ervin, Jason Buroker, Taylor Cummins, Anna W. Byars, Craig Scholle, Leonid Rozhkov, Paul S. Horn, Jeffrey R. Tenney, Hansel M. Greiner, James L. Leach, Jesse Skoch, Francesco T. Mangano, Katherine D. Holland, Ravindra Arya   +13 more
wiley   +1 more source

Development of High-Throughput Genomic Resources to Inform White-Tailed Deer Population and Disease Management. [PDF]

Mol Ecol Resour
Navarro D, Latch EK, Tallon AK, Ott-Conn CN, DeYoung RW, Walsh DP, Euclide PT, R G C, Larson WA, Seetharam AS, Severin AJ, Reecy JM, Hu ZL, Cantrell JR, Carstensen M, Caudell JN, Killmaster CH, Lockwood ML, McKinley WT, Norton AS, Schuler KL, Storm DJ, Sumners JA, Walter WD, Blanchong JA.   +24 more
europepmc   +1 more source

Compensatory rearrangement of parvalbumin interneuron voltage‐gated sodium channel subunits in a mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Heterozygous loss‐of‐function variants in the gene SCN1A, which encodes the voltage‐gated sodium channel (VGSC) pore‐forming (α) subunit NaV1.1, lead to a spectrum of neurological disease, including Dravet syndrome. NaV1.1 is prominently expressed at the proximal portion of the axon initial segment (AIS) of fast‐spiking γ‐aminobutyric ...
Ania K. Dabrowski, Ala Somarowthu, Sophie R. Liebergall, Damaris N. Lorenzo, Ethan M. Goldberg   +4 more
wiley   +1 more source

Spark: sparse hierarchical energy minimization for scalable prediction of RNA pseudoknots. [PDF]

Bioinformatics
Gray M, Will S, Jabbari H.
europepmc   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Distinct ARG profiles associated with class 1 integrons in municipal and industrial wastewater treatment plants. [PDF]

Environ Sci Ecotechnol
Zhang Y, Su Z, Qiu X, Liu H, Wen D, Chen L.   +5 more
europepmc   +1 more source

Multi‐Hazard Shaking‐Tsunami Fatality Risk Estimation for Coastal Communities

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT This study develops a multi‐hazard fatality risk model for a coastal community (Tofino) on Vancouver Island, Canada, subjected to earthquake‐tsunami threats from the Cascadia subduction megathrust events. The model incorporates variable population distributions and uncertain fatality rate models, in addition to other key model components, such
Katsuichiro Goda
wiley   +1 more source

Ultrahigh-density nested polar nanovortices with independently controllable conduction for ferroelectric memristor. [PDF]

Sci Adv
Taazayet WB, Wang J, Zhang Y, Qu S, Yang H, Fan Y, Han H, Ma J, Shao R, Huang H, Nan CW.   +10 more
europepmc   +1 more source