Results 31 to 40 of about 15,648,464 (247)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Enhancing wind speed forecasting accuracy using a GWO-nested CEEMDAN-CNN-BiLSTM model

ICT Express
This study introduces an advanced artificial model, grey wolf optimization (GWO)-nested complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN)-convolutional neural network (CNN)-bidirectional long short-term memory (BiLSTM), for ...
Quoc Bao Phan, Tuy Tan Nguyen
doaj   +1 more source

A linear mixed model, with non-stationary mean and covariance, for soil potassium based on gamma radiometry [PDF]

Biogeosciences, 2010
In this paper we present a linear mixed model for the potassium content of soil across a large region of eastern England in which the mean is modelled as a linear function of the passive gamma-ray emissions of the earth surface in the energy interval ...
K. A. Haskard, B. G. Rawlins, R. M. Lark
doaj   +1 more source

Joint tests of non-nested models and general error specifications [PDF]

Econometric Reviews, 1992
This paper is concerned with joint tests of non-nested models and simultaneous departures from homoskedasticity, serial independence and normality of the disturbance terms. Locally equivalent alternative models are used to construct joint tests since they provide a convenient way to incorporate more than one type of departure from the classical ...
Anil K. Bera, Michael McAleer, M. Hashem Pesaran, Mann J. Yoon   +3 more
openaire   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

TEMAP2.R: True and Error model analysis program in R [PDF]

Judgment and Decision Making, 2018
True and Error Theory (TET) provides a method to separate the variability of behavior into components due to changing true policy and to random error. TET is a testable theory that can serve as a statistical model, allowing one to evaluate substantive ...
Michael H. Birnbaum, Edika G. Quispe-Torreblanca   +1 more
doaj   +3 more sources

Multilevel IRT Modeling in Practice with the Package mlirt

Journal of Statistical Software, 2007
Variance component models are generally accepted for the analysis of hierarchical structured data. A shortcoming is that outcome variables are still treated as measured without an error.
Jean-Paul Fox
doaj  

Fuzzy Control for PVTOL Stabilization Based on Nested Saturation Functions

IEEE Access
In this paper, a new approach for stabilization of the PVTOL is presented, considering the Nested Saturation Controller (NSC) algorithm that has been designed based on the Lyapunov theory for stabilization problem of this mechanical system.
David Lara Alabazares, Eduardo Tzitzihua Garcia, Anai Camacho Luna, Abdelhamid Rabhi   +3 more
doaj   +1 more source