Results 91 to 100 of about 91,736 (294)

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Bayesian Analysis of Measurement Error Models Using Integrated Nested Laplace Approximations

Journal of the Royal Statistical Society Series C: Applied Statistics, 2014
SummaryTo account for measurement error (ME) in explanatory variables, Bayesian approaches provide a flexible framework, as expert knowledge can be incorporated in the prior distributions. Recently, integrated nested Laplace approximations have been proven to be a computationally convenient alternative to sampling approaches for Bayesian inference in ...
Muff, Stefanie, Riebler, Andrea, Held, Leonhard, Rue, Havard, Saner, Philippe   +4 more
openaire   +2 more sources

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

On Export-Led Growth: Is Manufacturing Exports a New Engine of Growth for Bangladesh? [PDF]

The study attempts to empirically verify the export-led growth hypothesis for Bangladesh. In this context, we examine whether manufacturing exports has become a new engine of export-led growth replacing total exports, as claimed by the so-called de novo ...
M.A.Hossain
core  

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

A Transition-Based Neural Framework for Chinese Nested Entity and Relation Recognition

IEEE Access
Entity and relation extraction for Chinese texts are typical performed in a pipelined fashion in the sense that by first segmenting sequence into words then recognizing entities and relations subsequently. However, this process often leads to the problem
Junchi Zhang, Mengchi Liu
doaj   +1 more source

A Comparison of Confidence Interval Methods of Fixed Effect in Nested Error Regression Model

SDÜ Fen Bilimleri Enstitüsü Dergisi, 2016
Linear mixed-effects models are very popular and powerful tools in many scientific fields such as zoology, biology, and education.  Estimators of fixed effects do not only depend on the variances of error terms but they also depend on random terms in mixed-effect models.
AKDUR, Hatice Tül Kübra, ÖZONUR, Deniz, BAYRAK, Hülya   +2 more
openaire   +6 more sources

Random Covariance Heterogeneity in Discrete Choice Models [PDF]

The area of discrete choice modelling has developed rapidly in recent years. In particular, continuing refinements of the Generalised Extreme Value (GEV) model family have permitted the representation of increasingly complex patterns of substitution and ...
Stephane Hess, John Polak, Denis Bolduc
core  

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

A Nested DUAL-axis Accelerometer with Enhanced Temperature Robustness for Testing Across the Entire Operational Temperature Range

Measurement Science Review
This paper investigates a nested biaxial micro-electro-mechanical systems (MEMS) accelerometer with low coupling error, derives the kinetic model equations of the accelerometer, and performs finite element simulations of the operating modes and ...
Ren Yanchao, Duan Guodong, Jiao Jingjing, Hu Xiaoping   +3 more
doaj   +2 more sources