Results 181 to 190 of about 47,875 (267)

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Advancing Genetic Stock Identification of Leatherback Turtles From Foraging Grounds in the Southwest Atlantic: Insights From Nuclear DNA (nDNA) Analysis. [PDF]

Ecol Evol
Prosdocimi L, Roden SE, Velez-Rubio GM, Fallabrino A, López-Mendilaharsu M, LaCasella EL, Dutton PH.   +6 more
europepmc   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Between the Atolls: Sea Turtle Nesting in the Maldives from 2018 to 2024. [PDF]

Animals (Basel)
Afeef I, Lloyd JR, Inan I, Mundy E, Stelfox M, Köhnk S.   +5 more
europepmc   +1 more source

High‐Throughput Mechanical Rupture of Nuclear Envelope and the Intracellular Dynamics of Massive Wound Repair

Advanced Science, EarlyView.
A microfluidic device with monolithically integrated nanostructures enables high‐throughput wounding of the cell membrane and nuclear envelope. The spatial distribution of charged multivesicular body protein 4B (CHMP4B) within the cell is mapped before and after wounding, showing involvement in repair of both the cell membrane and nuclear envelope ...
Apresio K. Fajrial, Leyla Akh, Stephanie E. Schneider, Wei Tan, Corey P. Neu, Xiaoyun Ding   +5 more
wiley   +1 more source

Integrating Beach Monitoring and Satellite Telemetry to Estimate Loggerhead Clutch Frequency in Brazil. [PDF]

Animals (Basel)
Lara PH, Stahelin G, Marcovaldi MÂ, Dos Santos AS, Swimmer Y, Mendilaharsu ML.   +5 more
europepmc   +1 more source

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

Breeding Biology of the Twite <i>Linaria flavirostris</i> in the North-Eastern Qinghai-Tibet Plateau, with Special Reference to Life-History Variation Across Latitudes and Altitudes. [PDF]

Animals (Basel)
Yan S, Zhang B, Li S.
europepmc   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Nightmare disorder shows reduced slow oscillation-dominant spindle coupling in NREM sleep. [PDF]

NPJ Biol Timing Sleep
Papp I, Cvetkovic Z, Biabani N, Rosenzweig J, Speicher C, Delogu A, Nesbitt AD, Drakatos P, Violante IR, Vilic D, Ballard C, O'Regan D, Goadsby PJ, Rosenzweig I.   +13 more
europepmc   +1 more source