Results 31 to 40 of about 49,607 (267)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Spiking buildings to avoid house martin (Delichon urban) nesting: is it a good choice?
Julius-Kühn-Archiv, 2011 We tested the effectiveness of installing spikes (® EcoPic E-5) on building eaves and windows to avoid the nesting of house martins. We found that spikes cannot prevent the nesting or reduce colony size.
Duarte, J. +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Frontiers in Ecology and Evolution, 2022 Diamondback terrapins (Malaclemys terrapin) are listed as Vulnerable by the IUCN Red List Index of Threatened Species. Among the challenges terrapins encounter are habitat loss due to coastal development and sea level rise, mortality at all life stages ...
Joseph A. Butler +3 more
doaj +1 more source
Dermatology Reports, 2021 This case was presented at the on-line meeting on the ADOI platform held on October 27th 2021 by Dr Zardo.
Davide Zardo +2 more
openaire +3 more sources
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
Anais da Academia Brasileira de Ciências, 2021 Tawny-bellied Seedeater (Sporophila hypoxantha) is an endangered (in Brazil) grassland dependent species, whose breeding success remains poorly known hampering conservation measures on its breeding grounds.
ISMAEL FRANZ, CARLA S. FONTANA
doaj +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source