Results 41 to 50 of about 1,353 (263)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Feasibility of Solar Grid-Based Industrial Virtual Power Plant for Optimal Energy Scheduling: A Case of Indian Power Sector

Energies, 2022
The increased popularity of small-scale DER has replaced the well-established concept of conventional generating plants around the world. In the present energy scenario, a significant share of energy production now comes from the grid integrated DERs ...
Harpreet Sharma, Sachin Mishra, Javed Dhillon, Naveen Kumar Sharma, Mohit Bajaj, Rizwan Tariq, Ateeq Ur Rehman, Muhammad Shafiq, Habib Hamam   +8 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Net Metering Prediction in Prosumer Building With Temporal Fusion Transformer Models

IEEE Access
The growing global demand for electrical energy, together with the significant problem of increasing carbon dioxide emissions, have become urgent issues. The inefficient use of electricity exacerbates these challenges.
Sorawut Jittanon, Yodthong Mensin, Nipon Ketjoy, Chakkrit Termritthikun   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Techno-economic optimization of island-based hybrid renewable microgrids under regulatory uncertainty: a policy-constrained genetic algorithm framework with hydrokinetic integration

Frontiers in Energy Research
The decarbonization of islanded village energy systems is constrained not only by the intermittency of renewable generation but also by the regulatory frameworks that govern grid interaction. This study develops and validates a policy-constrained Genetic
Nikolaos Sifakis, Nikolaos Galyfianakis, Dimitrios Cholidis, George Arampatzis   +3 more
doaj   +1 more source

Blockchain-Modeled Edge-Computing-Based Smart Home Monitoring System with Energy Usage Prediction

Sensors, 2023
Internet of Things (IoT) has made significant strides in energy management systems recently. Due to the continually increasing cost of energy, supply–demand disparities, and rising carbon footprints, the need for smart homes for monitoring, managing, and
Faiza Iqbal, Ayesha Altaf, Zeest Waris, Daniel Gavilanes Aray, Miguel Angel López Flores, Isabel de la Torre Díez, Imran Ashraf   +6 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source