Results 51 to 60 of about 1,353 (263)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Empowering Active Users: A Case Study with Economic Analysis of the Electric Energy Cost Calculation Post-Net-Metering Abolition in Slovenia

Energies
This paper addresses the issue of the abolition of annual net metering in Slovenia and compares the electric energy costs for the studied active user after the abolition. The article also provides an exploration of the role played by an aggregator, which
Eva Tratnik, Miloš Beković
doaj   +1 more source

Evaluation of the Cost-Effectiveness of the Installation of Heat-Cost Allocators in Multifamily Buildings in Croatia

Energies, 2019
In order to improve energy efficiency, the Croatian government introduced an individual metering obligation for all district heat network users. The purpose of the research was to evaluate this policy measure regarding its effects on tenants’ ...
Sunčana Slijepčević, Davor Mikulić, Kristijan Horvat   +2 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Sizing Merchant Energy Storage for Maximum Revenues Considering Net Metering and Ancillary Services

IEEE Access
As prices for energy storage (ES) decline, merchant-owned ES units have an opportunity to be profitable if they earn revenue from multiple streams. Most papers in the literature provide a simplistic view, and do not capture practical tariff structure of ...
Jessie Ma, Bala Venkatesh
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Cost Saving Potential of Grid-tied Solar Photovoltaic-based Hybrid Energy System in the Philippine Industrial Sector

Chemical Engineering Transactions, 2019
The Philippine Industrial Sector contributes USD 124x109 (~PHP 6.5x1012) or about 1/3 in the economy. However, the electricity cost, which is 2nd highest in Asia, constitutes up to 10 % of their total operating expenses.
Patrick Gregory Jara, Michael Tan Castro, Eugene A. Esparcia, Carl Michael F. Odulio, Joey Duran Ocon   +4 more
doaj   +1 more source

Detection of False-Reading Attacks in the AMI Net-Metering System

CoRR, 2020
In smart grid, malicious customers may compromise their smart meters (SMs) to report false readings to achieve financial gains illegally. Reporting false readings not only causes hefty financial losses to the utility but may also degrade the grid performance because the reported readings are used for energy management. This paper is the first work that
Mahmoud M. Badr, Mohamed I. Ibrahem, Mohamed Mahmoud 0001, Mostafa M. Fouda, Waleed Alasmary   +4 more
openaire   +3 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source