Results 171 to 180 of about 1,883,994 (277)

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Case Report: Neutrophil extracellular trap formation in palisaded neutrophilic granulomatous dermatitis. [PDF]

open access: yesFront Immunol
Minai L   +6 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Viloxazine Increases Extracellular Concentrations of Norepinephrine, Dopamine, and Serotonin in the Rat Prefrontal Cortex at Doses Relevant for the Treatment of Attention-Deficit/Hyperactivity Disorder

open access: yesJournal of Experimental Pharmacology
Jennie Garcia-Olivares,1 Brittney Yegla,1 Frank P Bymaster,2 Jami Earnest,1 Jennifer Koch,1 Chungping Yu,1 Jonathan Rubin1 1Supernus Pharmaceuticals, Inc., Rockville, MD, USA; 2Bymaster Neuroscience Consulting, Green Cove Springs, FL, USACorrespondence ...
Garcia-Olivares J   +6 more
doaj  

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Brazil at the Forefront: What Does It Take To Be Net-Zero by 2040. [PDF]

open access: yesGlob Chang Biol
Angelkorte G   +15 more
europepmc   +1 more source

NET Activity Report: March-December 1983

open access: yes, 1983
MARTONE, Raffaele, in NET Team
core  

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