Results 71 to 80 of about 15,770,275 (303)

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

open access: yesMolecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis   +20 more
wiley   +1 more source

Compensating the Net Cost of Universal Postal Services [PDF]

open access: yes
This paper analyzes the net cost of universal service obligations in the postal sector after full liberalization and the potential burden they represent for the universal service provider.
Christian Jaag
core  

LCU-Net: A novel low-cost U-Net for environmental microorganism image segmentation

open access: yes, 2021
In this paper, we propose a novel Low-cost U-Net (LCU-Net) for the Environmental Microorganism (EM) image segmentation task to assist microbiologists in detecting and identifying EMs more effectively.
Li, Chen   +18 more
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

Design of an Optimal off-grid Hybrid Energy System for a Rural Community

open access: yesJurnal Nasional Teknik Elektro, 2018
This paper presents an optimized off-grid PV-diesel generator-battery hybrid energy system for application in an un-electrified rural community and further outlines a procedure for designing such an economical and technically feasible hybrid system.
Wemogar Elijah Borweh   +2 more
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Techno-Economic Optimization of Solar-Powered EV Charging Stations in Muscat, Oman using HOMER Grid

open access: yesInternational Transactions on Electrical Engineering and Computer Science
International demand for EVs is only exceeded by the need for reliable and sustainable charging infrastructure. Oman may cut carbon emissions and fossil fuel use with this adjustment, but it strains the power infrastructure and requires solar-based EV ...
Santoshi Kanagala   +2 more
doaj   +1 more source

Costing the distribution of insecticide-treated nets: a review of cost and cost-effectiveness studies to provide guidance on standardization of costing methodology. [PDF]

open access: yes, 2006
BACKGROUND: Insecticide-treated nets (ITNs) are an effective and cost-effective means of malaria control. Scaling-up coverage of ITNs is challenging. It requires substantial resources and there are a number of strategies to choose from.
Kolaczinski, Jan   +7 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

ECONOMIC FEASIBILITY FOR THE PRODUCTION OF LIVE BAITS OF LAMBARI (Deuterodon iguape) IN RECIRCULATION SYSTEM

open access: yesBoletim do Instituto de Pesca, 2019
Sport fishing is a growing segment in the fishing sector in Brazil. It is, however, an activity that depends upon young shrimp and fish offer to supply live bait demand, its extraction might result on overfishing and compromise natural stock.
Marcelo Barbosa Henriques   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy