Results 121 to 130 of about 6,067,770 (256)
Advanced Science, EarlyView.In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang +13 more
wiley +1 more source
Advanced Science, EarlyView.Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang +20 more
wiley +1 more source
AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing
Advanced Science, EarlyView.A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li +8 more
wiley +1 more source
, 2010 We have investigated the contributions of three dominant macrophyte species Deyeuxia angustifolia Carex lasiocarpa and Carex pseudocuraica (covering about 10 304 km(2)) to carbon (C) nitrogen (N) and phosphorus (P) stocks in the largest freshwater marsh (
Wang, Yang +8 more
core
Advanced Science, EarlyView.B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu +4 more
wiley +1 more source
, 2009 China has made great economic achievements since the Reform and Opening policy implementation. Shenzhen as the representative city has experienced rapid urbanization and population growth.
Shi Peijun +4 more
core
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
A Terrestrial Ecosystem Carbon Sink Assessment Model Considering Forest Age Dynamics (CEVSA‐AgeD)
Journal of Advances in Modeling Earth SystemsThe large variation in net ecosystem productivity (NEP) with forest age was dominated by the dynamics of net primary productivity (NPP)–which in turn was determined by the different response slopes of gross primary productivity (GPP) and autotrophic ...
Mengyu Zhang +7 more
doaj +1 more source
Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control
Advanced Science, EarlyView.Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang +9 more
wiley +1 more source
Shuitu baochi yanjiu, 2019 This study is aimed to estimate the net primary productivity of vegetation in western Sichuan and analyze its spatial-temporal pattern and the relationship between net primary productivity (NPP) of vegetation and its driving factors, which provided a ...
CHEN Jie, XIAN Wei, CHEN Chunrong
doaj