Results 51 to 60 of about 3,665,214 (300)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Priority to end of life treatments? Views of the public in the Netherlands [PDF]

open access: yes, 2017
Objectives:Recent debates in the Netherlands on health care priority setting have focused on the relative value of gains generated by life-extending medicines for people with a terminal illness, mostly new cancer drugs.
Baker, Rachel   +3 more
core   +2 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

The Dutch Strategic and Operational Approach in the Indonesian War of Independence, 1945-1949

open access: yesScientia Militaria, 2019
The Indonesian War of Independence (1945–1949) and the Dutch attempt to combat the insurgency campaign by the Indonesian nationalists provides an excellent case study of how not to conduct a counter-insurgency war.
Scholtz, Leopold
doaj   +1 more source

Hollanda ve Çağdaş İslam Araştırmaları: NISIS (Hollanda Üniversitelerarası İslam Araştırmaları Okulu)

open access: yesAtebe, 2022
Bu çalışmada Hollanda’da, İslam Araştırmaları alanında son yirmi küsur yılda üretilmiş olan akademik müktesebat ele alınmıştır. Makalede Hollanda’da İslam Araştırmaları alanında faaliyet gösteren Netherlands Interuniversity School for Islamic Studies ...
Murat Kayalık
doaj   +1 more source

Use of different sources of information in maintaining standards: examples from the Netherlands [PDF]

open access: yes, 2012
In the different tests and examinations that are used at a national level in the Netherlands, a variety of equating and linking procedures are applied to maintain assessment standards. This chapter presents an overview of potential sources of information
Beguin, Anton
core   +2 more sources

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

A multicenter retrospective cohort study on incidence and diagnostics in emergency department patients with acute vestibular syndrome [PDF]

open access: yesClinical and Experimental Emergency Medicine
Objective Acute vestibular syndrome (AVS) is a common symptom experienced by emergency department (ED) patients. Differentiating a peripheral from central etiology poses a challenge, and clinical practice lacks a uniform diagnostic approach.
Renske Eveline Henriëtte Maria Bijl   +8 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Organic agriculture in the Netherlands [PDF]

open access: yes, 2009
Dutch organic agriculture has unique characteristics and peculiarities. It is still a relatively small sector compared to conventional agriculture in the Netherlands.
Hommes, M., Sukkel, W.
core   +1 more source

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