Results 91 to 100 of about 2,214,703 (288)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Authoritarian practices on the rise? Reflections from a Médecins Sans Frontières research programme on the engagement between international humanitarian non-governmental organisations and states

Frontiers in Political Science
The engagement between international humanitarian non-government organisations (INGOs) and states has long been a contested space. This theme has become more pertinent against the backdrop of a widely perceived global ‘rise in authoritarianism’.
Andrew Cunningham, Sean Healy
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Network Analysis

, 2021
Kristine Maciejewski, Jacopo Baggio
  +6 more sources

Robustness analysis of denoising neural networks for bone scintigraphy

, 2022
Ákos Kovács, Tamás Bükki, Gábor Légrádi, Nora J. Meszaros, Gyula Z. Kovacs, Peter Prajczer, Istvan Tamaga, Zoltan Seress, Gábor Kiszler, Attila Forgács, Sándor Barna, Ildikó Garai, András Horváth   +12 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Measures for Network Structural Dependency Analysis [PDF]

, 2018
Yordanos Tibebu Woldeyohannes, Yuming Jiang   +1 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Characterization of liver, adipose, and fecal microbiome in obese patients with MASLD: links with disease severity and metabolic dysfunction parameters

Microbiome
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a range of histological findings from the generally benign simple steatosis to steatohepatitis (MASH) which can progress to fibrosis and cirrhosis.
Katherine J. P. Schwenger, Julia K. Copeland, Yasaman Ghorbani, Lina Chen, Elena M. Comelli, David S. Guttman, Sandra E. Fischer, Timothy D. Jackson, Allan Okrainec, Johane P. Allard   +9 more
doaj   +1 more source

Multi-Level Intertemporal Attention-Guided Network for Change Detection in Remote Sensing Images

Remote Sensing
Change detection (CD) is detecting and evaluating surface changes by comparing Remote Sensing Images (RSIs) at different times, which is of great significance for environmental protection and urban planning.
Shuo Liu, Qinyu Zhang, Yuhang Zhang, Xiaochen Niu, Wuxia Zhang, Fei Xie   +5 more
doaj   +1 more source