Results 141 to 150 of about 4,643,840 (321)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Computer Design of Electricity Supply Networks by a Heuristic Method [PDF]
, 1966 R. M. Burstall
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cyclists' exposure to traffic-generated air pollution in multi-modal transportation network design problem. [PDF]
PLoS One, 2023 Mortazavi Moghaddam E +3 more
europepmc +1 more source
An Approach for Modelling Wireless Sensor Networks: Focusing on the Design Concept and Energy Awareness [PDF]
, 2023 Michel Bakni +4 more
openalex
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Sustainable urban mobility: Flexible bus service network design in the post-pandemic era. [PDF]
Sustain Cities Soc, 2023 Tan Z, Shao S, Zhang X, Shang WL.
europepmc +1 more source
Design of Neural Network based MPPT(Maximum Power Point Tracking) Algorithm for Efficient Energy Management in Urban Wind Turbine Generating System [PDF]
, 2009 Seung‐Young Kim, Sung‐Ho Kim
openalex +1 more source