Results 31 to 40 of about 524,392 (268)
Modulation of the functional interfaces between retroviral intasomes and the human nucleosome
mBio, 2023 Infection by retroviruses as HIV-1 requires the stable integration of their genome into the host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called intasomes, and their interaction with the target DNA wrapped around ...
E. Mauro +18 more
doaj +1 more source
Equivalence of Additive and Multiplicative Coupling in Spiking Neural Networks
IEEE Access, 2023 Spiking neural network models characterize the emergent collective dynamics of circuits of biological neurons and help engineer neuro-inspired solutions across fields. Most dynamical systems’ models of spiking neural networks typically exhibit one
Georg Borner +2 more
doaj +1 more source
Alignment of dynamic networks [PDF]
Bioinformatics, 2017 Abstract Motivation Network alignment (NA) aims to find a node mapping that conserves similar regions between compared networks. NA is applicable to many fields, including computational biology, where NA can guide the transfer of biological knowledge from well- to poorly-studied species across aligned
Vipin Vijayan +2 more
openaire +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Dynamic stop pooling for flexible and sustainable ride sharing
New Journal of Physics, 2022 Ride sharing—the bundling of simultaneous trips of several people in one vehicle—may help to reduce the carbon footprint of human mobility. However, the complex collective dynamics pose a challenge when predicting the efficiency and sustainability of ...
Charlotte Lotze +3 more
doaj +1 more source
Neurobiology of Disease, 2023 Evoked resonant neural activity (ERNA) is induced by subthalamic deep brain stimulation (DBS) and was recently suggested as a marker of lead placement and contact selection in Parkinson's disease. Yet, its underlying mechanisms and how it is modulated by
Christoph Wiest +13 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Model-free inference of direct network interactions from nonlinear collective dynamics
Nature Communications, 2017 Network dynamical systems can represent the interactions involved in the collective dynamics of gene regulatory networks or metabolic circuits. Here Casadiego et al.
Jose Casadiego +3 more
doaj +1 more source
Using data-driven agent-based models for forecasting emerging infectious diseases
Epidemics, 2018 Producing timely, well-informed and reliable forecasts for an ongoing epidemic of an emerging infectious disease is a huge challenge. Epidemiologists and policy makers have to deal with poor data quality, limited understanding of the disease dynamics ...
Srinivasan Venkatramanan +5 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source