Results 121 to 130 of about 2,676 (252)

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

open access: yesAdvanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao   +12 more
wiley   +1 more source

Cloud Network Function Virtualization (NFV)

open access: yesInternational Journal For Multidisciplinary Research
Cloud Network Function Virtualization (NFV) is a groundbreaking technology that revolutionizes the way network services are delivered. By virtualizing network functions, NFV enables faster deployment, scalability, and management of network services. This article explores the benefits and use cases of NFV, including virtualized load balancers, firewalls,
openaire   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

open access: yesAdvanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

open access: yesAdvanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Spintronic Bayesian Hardware Driven by Stochastic Magnetic Domain Wall Dynamics

open access: yesAdvanced Science, EarlyView.
Magnetic Probabilistic Computing (MPC) utilizes intrinsic stochastic dynamics in domain walls to establish a hardware foundation for uncertainty‐aware artificial intelligence. Thermally driven domain‐wall fluctuations, voltage‐controlled magnetic anisotropy, and TMR readout enable fully electrical, tunable probabilistic inference.
Tianyi Wang   +11 more
wiley   +1 more source

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