Results 231 to 240 of about 38,322 (299)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Research on cloud-edge-end distributed collaborative computing based on deep reinforcement learning. [PDF]

Sci Rep
Wu C, Ye Q, Wang Y, Zhang D, Zhang W, Jiang X.   +5 more
europepmc   +1 more source

Seamless Resource Sharing in Wearable Networks by Application Function Virtualization

, 2018
Harini Kolamunna, Kanchana Thilakarathna, Diego Perino, Dwight Makaroff, Aruna Seneviratne   +4 more
openalex   +2 more sources

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
ABSTRACT This special issue marking the University of Bath's 60th anniversary offers an opportunity to reflect on nearly a decade of research into the evolution of gene regulatory networks (GRNs) from members of the lab and elsewhere. Our goal is to understand how GRNs rewire and how new transcription factor (TF) functions evolve. Using an experimental
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Slice-aware 5G network orchestration framework based on dual-slice isolation and management strategy (D-SIMS). [PDF]

Sci Rep
Venkatapathy S, Srinivasan T, Lee OS, Jayaraman R, Jo HG, Ra IH.   +5 more
europepmc   +1 more source

TVRAVNF: an efficient low-cost TEE-based virtual remote attestation scheme for virtual network functions [PDF]

Jie Yuan, Rui Xu, Xinghai Wei, Keji Miao, Dongxiao Liu   +4 more
openalex   +1 more source

Reconstructing Coherent Functional Landscape From Multi‐Modal Multi‐Slice Spatial Transcriptomics by a Variational Spatial Gaussian Process

Advanced Science, EarlyView.
This study introduces stVGP, a variational spatial Gaussian process framework for multi‐modal, multi‐slice spatial transcriptomics. By integrating histological and genomic data through hybrid alignment and attention‐based fusion, stVGP reconstructs coherent 3D functional landscapes.
Zedong Wang, Bowen Fu, Chuanchao Zhang, Xiaoping Liu   +3 more
wiley   +1 more source

SharpCEEWPServer: A Lightweight Server for the Communication Protocol of China Earthquake Early Warning Systems. [PDF]

Sensors (Basel)
Li L, Li J, Xiang W, Liu Z, Liao W, Zhang L.   +5 more
europepmc   +1 more source

Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli

Advanced Science, EarlyView.
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng, Hao Liu, Haolin Han, Meng Meng, Shaojie Wang, Tianwei Tan, Haijia Su   +6 more
wiley   +1 more source