Results 51 to 60 of about 605,479 (264)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

What Roles Do Local Governments Play in Chinese Urban Energy Transition?

Systems
The energy transition is a common challenge faced by all nations. Cities, as the primary hubs of energy consumption, serve as the “front line” in this energy transition. Existing literature acknowledges the importance of governments in energy transitions,
Ling Liu, Rui Zhou, Fangfang Wang
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

ON VULNERABILITY MEASURES OF NETWORKS

Croatian Operational Research Review, 2013
As links and nodes of interconnection networks are exposed to failures, one of the most important features of a practical networks design is fault tolerance. Vulnerability measures of communication networks are discussed including the connectivities, fault diameters, and measures based on Hosoya-Wiener polynomial.
Erveš, Rija, Rupnik Poklukar, Darja, Žerovnik, Janez   +2 more
openaire   +3 more sources

A Dissimilarity Measure for Semidirected Networks

IEEE Transactions on Computational Biology and Bioinformatics
Semidirected networks have received interest in evolutionary biology as the appropriate generalization of unrooted trees to networks, in which some but not all edges are directed. Yet these networks lack proper theoretical study. We define here a general class of semidirected phylogenetic networks, with a stable set of leaves, tree nodes and hybrid ...
Michael Maxfield, Jingcheng Xu, Cécile Ané   +2 more
openaire   +3 more sources

Self adaptive method for end-to-end available bandwidth estimation

Tongxin xuebao, 2008
A low overhead, self adaptive method for end-to-end available bandwidth estimation was proposed. Firstly, on low utilization path, the mathematic equation between the probability that input probe gap increases caused by CT pack-ets and the distribution ...
ZHOU An-fu, LIU Min, LI Zhong-cheng, XIE Gao-gang   +3 more
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Network Measurement and Performance Analysis at Server Side

Future Internet, 2018
Network performance diagnostics is an important topic that has been studied since the Internet was invented. However, it remains a challenging task, while the network evolves and becomes more and more complicated over time.
Guang-Qian Peng, Guangtao Xue, Yi-Chao Chen   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source