Results 31 to 40 of about 79,857 (263)
Journal of Allergy and Clinical Immunology, 2023 Atopic dermatitis (AD) is a common skin condition with multiple topical treatment options, but uncertain comparative effects.We sought to systematically synthesize the benefits and harms of AD prescription topical treatments.For the 2023 American Academy of Allergy, Asthma & Immunology and American College of Allergy, Asthma, and Immunology Joint Task ...
Derek K. Chu +39 more
openaire +4 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Heterogeneous Ensemble Deep Learning Model for Enhanced Arabic Sentiment Analysis
Sensors, 2022 Sentiment analysis was nominated as a hot research topic a decade ago for its increasing importance in analyzing the people’s opinions extracted from social media platforms.
Hager Saleh +4 more
doaj +1 more source
The efficacy of combined phototherapy with topical therapy in vitiligo: a network meta-analysis
Journal of Dermatological TreatmentThe comparative effects of phototherapy and topical therapy in patients with vitiligo remain unclear. A network meta-analysis (NMA) was conducted to assess which combination therapy was more beneficial for patients with vitiligo. This study analyzed phototherapy, including narrowband ultraviolet B (NB-UVB) and 308-nm excimer laser/light (EL) combined ...
Liping Luo +6 more
openaire +3 more sources
Effectiveness of topical and ablative therapies in treatment of anogenital warts: a systematic review and network meta-analysis [PDF]
BMJ Open, 2019 Objective To generate estimates of comparative clinical effectiveness for interventions used in the treatment of anogenital warts (AGWs) through the systematic review, appraisal and synthesis of data from randomised controlled trials (RCTs). Design
Steven Edwards +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
BMJ Open, 2020 Introduction Patients with type 2 diabetes mellitus (T2DM) are at risk for a variety of severe debilitating effects. One of the most serious complications experienced by patients with T2DM are skeletal diseases caused by changes in the bone ...
Stephanie Sanger +5 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Immunotherapy with immune checkpoint inhibitor (ICI) drugs is gradually becoming a hot topic in cancer treatment. To comprehensively evaluate the safety and efficacy of ICI drugs, we employed the Bayesian model and conducted a network meta-analysis in ...
Ze Xiang +10 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source