Results 91 to 100 of about 4,413,107 (338)
Budget impact analysis of implementing a lung cancer screening in high-risk population in Spain
Gaceta SanitariaObjective: To analyze the cost of implementing a population-based lung cancer screening program using low-dose radiation computed tomography (CT) in a high-risk population in Spain.
Aránzazu Hernández-Yumar +3 more
doaj +1 more source
Performance Test of Spacex’s Starlink: An Empirical Review [PDF]
JES: Journal of Engineering SciencesIn recent years, there has been significant interest in the deployment of Low Earth Orbit (LEO) satellite constellations as a potential solution to provide broadband internet access to remote regions [1].
OSEMWEGIE OMOROGIUWA +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Retraction Note to: Research on coastal atmospheric change and Latin dance performance based on target detection network [PDF]
, 2021 Fan Rao
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Performance of Queueing Models for MISO Content-Centric Networks. [PDF]
, 2021 Ramkumar Raghu +2 more
openalex
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Quantum Field Tensor Model of Telecommunication Network Objects Interaction Based on Lie Groups
Proceedings of the International Conference on Applied Innovations in ITThis research explores the application of quantum physics methodologies to analyse digital flows within telecommunication networks. This study introduces a novel tensor model, grounded in the SU(2) Lie group, designed to simulate symmetric and asymmetric
Victor Tikhonov +6 more
doaj +1 more source