Results 71 to 80 of about 4,413,107 (338)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
High Performance Networks [PDF]
, 2010 Interconnection networks are key elements in current scalable compute and storage systems, such as parallel computers, networks of workstations, clusters, and even on-chip interconnects. In all these systems, common aspects of communication are of high interest, including advances in the design, implementation, and evaluation of interconnection ...
Alfonso Urso +3 more
openaire +3 more sources
A mechanistic model of connector hubs, modularity, and cognition
, 2018 The human brain network is modular--comprised of communities of tightly interconnected nodes. This network contains local hubs, which have many connections within their own communities, and connector hubs, which have connections diversely distributed ...
Bassett, Danielle S. +3 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Yearbook of Swiss Administrative Sciences, 2013 This paper explores the role that Government should play when networks are established for the provision of public services. Should Government leave and give overall autonomy to the networked organizations?
Daniela Cristofoli, Laura Maccio’
doaj +1 more source
Erratum to “Effect of Channel Fading and Time-to-Trigger Duration on Handover Performance in UAV Networks” [PDF]
, 2021 Yuan He +3 more
openalex +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Training Behavior of Sparse Neural Network Topologies
, 2019 Improvements in the performance of deep neural networks have often come through the design of larger and more complex networks. As a result, fast memory is a significant limiting factor in our ability to improve network performance.
Alford, Simon +3 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source