Results 81 to 90 of about 19,754,425 (354)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Analyzing Transportation Network Vulnerability to Critical-Link Attacks Through Topology Changes and Traffic Volume Assessment

Applied Sciences
As a critical infrastructure, the transportation network impacts health, safety, comfort, and the economy, making it highly vulnerable to disruptions that significantly affect social and economic well-being.
Kalpana Ldchn, Teppei Kato, Kazushi Sano
doaj   +1 more source

High Performance Networks [PDF]

, 2010
Interconnection networks are key elements in current scalable compute and storage systems, such as parallel computers, networks of workstations, clusters, and even on-chip interconnects. In all these systems, common aspects of communication are of high interest, including advances in the design, implementation, and evaluation of interconnection ...
Alfonso Urso, Giuseppe Di Fatta, Ulrich Bruening, Jose' Flich   +3 more
openaire   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

The success of service delivery-networks: You can maximize your managerial efforts, but Governments set your frontiers

Yearbook of Swiss Administrative Sciences, 2013
This paper explores the role that Government should play when networks are established for the provision of public services. Should Government leave and give overall autonomy to the networked organizations?
Daniela Cristofoli, Laura Maccio’
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Analysis of Capacity Limitation in Nigerian GSM Networks and the Effects on Service Providers and Subscribers [PDF]

, 2007
The performance of GSM network is measured in terms of KPIs (Key Performance Indicators) based on statistics generated from the network. The most important of these performance indicators from the operators’ perspective are BER (bit error rate), the ...
Adetiba, E., Matthews, V. O.
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

An Efficient Method to Enhance IP Telephony Performance in IPV6 Networks [PDF]

, 2021
Mosleh M. Abualhaj, Sumaya N. Al-Khatib, Qusai Y. Shambour, Ahmad Adel Abu-Shareha   +3 more
openalex   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source