Oxidized Carbon Nanoparticles Enhance Cellular Energetics With Application to Injured Brain
Advanced Healthcare Materials, Volume 14, Issue 8, March 25, 2025.Oxidized carbon nanozymes (OCNs) that catalyze the dismutation of superoxide radical and oxidation of reduced nicotinamide adenine dinucleotide (NADH) to NAD+ promote glycolytic and mitochondrial energy metabolism under impaired conditions observed in traumatic brain injury with hemorrhage.
Karthik Mouli +11 more
wiley +1 more source
Allium Vegetables Intake and Digestive System Cancer Risk: A Study Based on Mendelian Randomization, Network Pharmacology and Molecular Docking [PDF]
arXivBackground: Allium vegetables (garlic and onion) are one of the flavorings in people's daily diets. Observational studies suggest that intake of allium vegetables may be correlated with a lower incidence of digestive system cancers. However, the existence of a causal relationship is still controversial due to confounding factors and reverse causation ...
arxiv
A Systematic Review and Network Meta-Analysis of Pharmacological Therapies Used for Patients with Advanced Parkinson's Disease [PDF]
, 2014 Shijie Ren +4 more
openalex +1 more source
Protein Functional Families to characterise drug-target interactions. [PDF]
, 2017 The quest for “magic bullets” has been the driving force in drug discovery during the last two decades. However, the increasing rate of drug failure over this period has occurred concurrently with the assumption that a drug is a selective ligand for a ...
Moya-García, Aurelio
core
Kidney Fibrosis In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models
Advanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.This review discusses kidney diseases with a focus on kidney fibrosis and the models currently used. It highlights the limitations of animal and 2D in vitro models in replicating human kidney anatomy and physiology. Consequently, there is a significant need for humanized 3D in vitro models, such as 3D cell aggregates, membranes and hydrogels, on‐chip ...
Gabriele Addario +2 more
wiley +1 more source
A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans [PDF]
, 2015 Shaun Calvert +5 more
openalex +1 more source
Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.This study presents an innovative in vitro model of a human left ventricle using biofunctionalized PDMS membranes and human iPSC‐derived cardiomyocytes. The engineered ventricle demonstrates stable, long‐term pulsatile flow, and physiological responses to cardioactive drugs.
Christoph Kuckelkorn +6 more
wiley +1 more source
Frontiers in PharmacologyIntroductionEvidence of the benefits of cordycepin (Cpn) for treating obesity is accumulating, but detailed knowledge of its therapeutic targets and mechanisms remains limited.
Yu Liao +4 more
doaj +1 more source
Systems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: Comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex [PDF]
, 2015 Suhong Yu +12 more
openalex +1 more source
Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics. [PDF]
, 2020 Do, Thao P +7 more
core +2 more sources