Results 181 to 190 of about 628,285 (376)

Investigating the Mechanism of Action of Ipomoea pes-caprae in the Treatment of Rheumatoid Arthritis Based on Serum Metabolomics and Network Pharmacology

Marine Drugs
Ipomoea pes-caprae (L.) Sweet (Convolvulaceae) is a commonly used marine Chinese medicine in the coastal areas of southern China. Traditionally, it has been used in the treatment of rheumatoid arthritis (RA).
Fangfei Zhong, Siwei Li, Xianglong Pan, Juan Wen, Jinling Xie, Zhengcai Du, Erwei Hao, Jiagang Deng, Xiaotao Hou   +8 more
doaj   +1 more source

Joint Meeting of the Society for Cutaneous Ultrastructure Research (32nd Annual Meeting of SCUR) with the International Society of Skin Pharmacology and Physiology (ISP) and the European Epidermal Barrier Research Group (Network) 1st–4th June 2005 HAMBURG, Germany

, 2005
J. R. McMillan, Masashi Akiyama, Keiji Yasukawa, J.A. McGrath, Hisao Shimizu   +4 more
openalex   +1 more source

High performance graph analysis on parallel architectures [PDF]

, 2016
PhD ThesisOver the last decade pharmacology has been developing computational methods to enhance drug development and testing. A computational method called network pharmacology uses graph analysis tools to determine protein target sets that can lead ...
Grivas, Athanasios K
core  

Rod‐shaped Polymerized Salicylic Acid Particles Modulate Neutrophil Transendothelial Migration in Acute Inflammation

Advanced Healthcare Materials, EarlyView.
Rod‐shaped particles outperform spherical particles of the same volume in preventing neutrophil infiltration to inflamed areas, both in vitro and in vivo. This therapeutic effectiveness is attributed to better cell targeting and decreased cell motility, resulting from the geometry‐driven phagocytosis and inhibited actin polymerization.
M. Valentina Guevara, Emma R. Brannon, Daniel Kupor, Mariana R.N. Lima, Logan D. Piegols, Michael L. Felder, Kathryn E. Uhrich, Omolola Eniola‐Adefeso   +7 more
wiley   +1 more source

A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals

Advanced Healthcare Materials, EarlyView.
A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin, Kyungtae Kim, Jaeseung Lee, Johyeon Nam, Eunha Baeg, Chaeyeon You, Hanseul Choi, Minji Kim, Chun Kee Chung, Jae Geun Kim, Jong Hyun Ahn, Miryung Han, Jibum Kim, Sungchil Yang, Sung Q Lee, Sunggu Yang   +15 more
wiley   +1 more source

Quantifying the Dynamics of Innovation Abandonment Across Scientific, Technological, Commercial, and Pharmacological Domains [PDF]

arXiv
Despite the vast literature on the diffusion of innovations that impacts a broad range of disciplines, our understanding of the abandonment of innovations remains limited yet is essential for a deeper understanding of the innovation lifecycle. Here, we analyze four large-scale datasets that capture the temporal and structural patterns of innovation ...
arxiv  

Network-Based Relating Pharmacological and Genomic Spaces for Drug Target Identification

, 2010
Shiwen Zhao, Shao Li
openalex   +2 more sources

A Dual‐Layer Hydrogel Barrier Integrating Bio‐Adhesive and Anti‐Adhesive Properties Prevents Postoperative Abdominal Adhesions

Advanced Healthcare Materials, Volume 14, Issue 11, April 25, 2025.
A new dual‐layer hydrogel barrier for preventing postoperative abdominal adhesions is developed. The inner layer, consisting of polyethyleneimine (PEI) and thioctic acid (TA), enhanced adhesion to moist tissues. The outer layer combines zwitterionic, thermoresponsive hyaluronic acid with anti‐inflammatory epigallocatechin gallate (EGCG) and forms a ...
Mena Asha Krishnan, Olawale A. Alimi, Mitchell Kuss, Tiffany N Razabdouski, Erika A Eksioglu, Bin Duan, Bo Liu   +6 more
wiley   +1 more source

Clinical relevance of cyclic GMP modulators: A translational success story of network pharmacology [PDF]

, 2016
JM Oettrich, VT Dao, Jeroen Frijhoff, PWM Kleikers, Ana I. Casas, Adrian J. Hobbs, Harald Schmidt   +6 more
openalex   +1 more source

Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons

Advanced Healthcare Materials, EarlyView.
This study introduces a novel chitosan‐based nanocarrier functionalized with a neurotropic protein for efficient siRNA delivery to neurons. The polyplexes demonstrate enhanced neuronal binding, retrograde transport, and PTEN silencing, promoting axonal outgrowth.
Ana P. Spencer, Adriana Vilaça, Miguel Xavier, Rafael Santos, Ariel Ionescu, María Lázaro, Victoria Leiro, Eran Perlson, Sofia C. Guimarães, Ben M. Maoz, Ana P. Pêgo   +10 more
wiley   +1 more source