Results 181 to 190 of about 7,014,814 (396)

Computational Molecular Networks and Network Pharmacology

open access: yesBioMed Research International, 2017
Kang Ning   +4 more
openaire   +3 more sources

Network pharmacology-based investigation of the pharmacological mechanisms of diosgenin in nonalcoholic steatohepatitis

open access: yesScientific Reports
The prevalence of nonalcoholic steatohepatitis (NASH) is rising annually, posing health and economic challenges, with limited treatments available. Diosgenin, a natural steroidal compound found in various plants, holds potential as a therapeutic candidate. Recent studies have confirmed diosgenin's anti-inflammatory and metabolism-modulating properties.
Peiyuan Gu   +7 more
openaire   +3 more sources

Animal‐Free Setup of a 3D Mature Adipocyte‐Macrophage Co‐Culture to Induce Inflammation In Vitro

open access: yesAdvanced Healthcare Materials, EarlyView.
A completely animal‐free 3D co‐culture is developed using human fat cells and immune cells. Animal‐based materials are replaced with gellan gum hydrogel and a serum‐free medium. Immune cells are effectively activated, producing specific inflammatory signals.
Sophia Nowakowski   +3 more
wiley   +1 more source

Investigating the Mechanism of Action of Ipomoea pes-caprae in the Treatment of Rheumatoid Arthritis Based on Serum Metabolomics and Network Pharmacology

open access: yesMarine Drugs
Ipomoea pes-caprae (L.) Sweet (Convolvulaceae) is a commonly used marine Chinese medicine in the coastal areas of southern China. Traditionally, it has been used in the treatment of rheumatoid arthritis (RA).
Fangfei Zhong   +8 more
doaj   +1 more source

Coagulation Matters: ATIII‐Enriched Biomolecular Corona Enhances the Hemocompatibility of PEG Nanoparticles

open access: yesAdvanced Healthcare Materials, EarlyView.
Engineering of a functional protein corona with a synergistic heparin‐ATIII complex significantly improves hemocompatibility of PEG nanoparticles. Through deliberate engineering of the protein corona, a 4‐fold reduction in coagulation activation (F1 + 2) without inducing adverse thromboinflammatory reactions (CD11b, C5a) is achieved without disrupting ...
Vaidehi Londhe   +5 more
wiley   +1 more source

Systems pharmacology – Towards the modeling of network interactions

open access: yesEuropean Journal of Pharmaceutical Sciences, 2016
Mechanism-based pharmacokinetic and pharmacodynamics (PKPD) and disease system (DS) models have been introduced in drug discovery and development research, to predict in a quantitative manner the effect of drug treatment in vivo in health and disease. This requires consideration of several fundamental properties of biological systems behavior including:
openaire   +3 more sources

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

open access: yesAdvanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi   +10 more
wiley   +1 more source

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