Results 191 to 200 of about 628,285 (376)

Therapeutic Effects of Qingchang Tongluo Decoction on Intestinal Fibrosis in Crohn’s Disease: Network Pharmacology, Molecular Docking and Experiment Validation

open access: yesDrug Design, Development and Therapy
Yanan Li,1,2,* Jingyi Hu,1,2,* Ryan Au,1– 3 Cheng Cheng,1,2 Feng Xu,1,2 Weiyang Li,1,2 Yuguang Wu,1,2 Yuan Cui,1,2 Lei Zhu,1,2 Hong Shen1,2 1Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, People’s Republic of ...
Li Y   +9 more
doaj  

Super‐Resolution Goes Viral: T4 Virus Particles as Versatile 3D‐Bio‐NanoRulers

open access: yesAdvanced Materials, Volume 37, Issue 12, March 26, 2025.
Various super‐resolution fluorescence microscopy methods achieve nanoscale resolution, vital for visualizing subcellular structures. Choosing suitable biological standards is challenging, demanding precise geometry and specific labeling capabilities. Utilizing T4 bacteriophage as a 3D‐Bio‐NanoRuler is proposed.
José Ignacio Gallea   +10 more
wiley   +1 more source

Danhong injection alleviates OGD-induced blood-brain barrier injury via VEGFR2/PI3K/AKT pathway based on network pharmacology and experimental evidence

open access: yesJournal of Holistic Integrative Pharmacy
Objective: Previous studies have shown that Danhong injection (DHI) has a protective effect on the blood-brain barrier (BBB) function after ischemic stroke.
Yutong Zhang   +5 more
doaj  

Effect of Renal Impairment on the Pharmacokinetics of Memantine

open access: yesJournal of Pharmacological Sciences, 2012
The effect of renal impairment on the pharmacokinetics of a single oral dose of memantine (10 mg) was determined in Japanese subjects. Subjects were assigned to four groups based on baseline creatinine clearance (CLCR): normal renal function (> 80 mL/min,
Takashi Moritoyo   +45 more
doaj  

Development of Bioorthogonally Degradable Tough Hydrogels Using Enamine N‐Oxide Based Crosslinkers

open access: yesAdvanced Materials, Volume 37, Issue 13, April 2, 2025.
Inducibly degradable enamine N‐oxide crosslinkers are integrated into tough double network hydrogels, enabling rapid and bioorthogonal degradation by aqueous diboron solutions. These chemical reagent‐responsive biomaterials maintain structural integrity during use while enabling rapid degradation when needed, making them ideal for applications in ...
Thomas T. Kim   +4 more
wiley   +1 more source

Qiditangshen Granules Alleviates Diabetic Nephropathy Podocyte Injury: A Network Pharmacology Study and Experimental Validation in Vivo and Vitro [PDF]

open access: yes
BACKGROUND: QiDiTangShen granules (QDTS), a traditional Chinese medicine (TCM) compound prescription, have remarkable efficacy in diabetic nephropathy (DN) patients, and their pharmacological mechanism needs further exploration. METHODS: According to the
Gao, Fei   +6 more
core   +1 more source

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