Results 191 to 200 of about 337,823 (305)

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Network pharmacology analysis and in vitro verification of the anti-sarcopenia effects of formononetin. [PDF]

Bioresour Bioprocess
Fang Y, Wei Z, Lei Z.
europepmc   +1 more source

Multiscale Acoustic Bubble Actuators Using Bioinspired Liquid‐Repellent Microstructures

Advanced Materials Technologies, EarlyView.
The article presents multiscale acoustic bubble actuators using bioinspired liquid‐repellent microstructures, enabling programmable trapping, pumping, mixing, and precise flow control. Mimicking springtail microstructures, these scalable actuators (200 µm–1 mm) offer multifunctionality in all‐in‐one devices, letter‐shaped arrays, and 3D cube ...
Cem Balda Dayan, Nima Mahkam, Nihal Olcay Dogan, Ville Liimatainen, Defne Hiz, Aleyna Ilgezdi, Daniel Razansky, Amirreza Aghakhani, Metin Sitti   +8 more
wiley   +1 more source

Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Cryptotanshinone Against Platelet Aggregation. [PDF]

Curr Issues Mol Biol
Huang J, Liu Z, Wang B, Qiu H, Chen Q, Xian J, Liu S, Shi X, Xia T, Tan X, Jiang W, Shen Y, Wang L, Feng J.   +13 more
europepmc   +1 more source

Neutral‐pH Electropolymerization of Aniline on Hierarchically Porous Laser‐Induced Graphene Electrodes for Dual Biosensing

Advanced Materials Technologies, EarlyView.
Neutral‐pH electropolymerization of aniline on laser‐induced graphene (LIG) produces stable, brush‐like polyaniline coatings without requiring acidic conditions. The resulting PANI–LIG electrodes exhibit enhanced electroactive surface area, efficient charge transfer, and dual sensing capability for β‐blockers and pH, providing a scalable platform ...
Angelika Łepek, Aiswarya Manohar, Mattia Pierpaoli, Robert Bogdanowicz, Łukasz Gaweł, Mohsen Khodadadi Yazdi, Jacek Ryl   +6 more
wiley   +1 more source

Exploring the mechanism of action of Kaixin San in treating dementia based on network pharmacology and molecular docking. [PDF]

Medicine (Baltimore)
Liu S, Zhang Z.
europepmc   +1 more source

BLOC: Buildable and Linkable Organ on a Chip

Advanced Materials Technologies, EarlyView.
We developed a “Buildable and Linkable Organ on a Chip” (BLOC) that can construct diverse microphysiological systems (MPSs). The BLOC is standardized to the same size and has one of the functions of “Culture,” “Control,” or “Analysis.” Users can freely configure various MPSs, including developing perfusion, cytotoxicity analysis, and biochemical ...
Yusuke Kimura, Hiroki Hamaguchi, Kotaro Oyama, Tomoko G. Oyama, Atsushi Kimura, Yasuhiro Ohshima, Noriko S. Ishioka, Mitsumasa Taguchi   +7 more
wiley   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Network pharmacology and molecular docking to explore the potential mechanism of Codonopsis pilosula delaying aging. [PDF]

Medicine (Baltimore)
Liu J, Zhang X, Jing X, Wang W, Li K.
europepmc   +1 more source

Nanophotonic Strategies for Chiral Biosensing: Nanoparticles, Metasurfaces, Magneto‐Optical, and Quantum Approaches

Advanced Photonics Research, EarlyView.
Recent advances in nanophotonics‐based chiral biosensing approaches are comprehensively reviewed, highlighting key trends, advantages, and limitations of each technology. Special attention is given to emerging strategies that exploit magneto‐optical and quantum plasmonic phenomena to enhance sensitivity down to the level of a few molecules, or even a ...
Jorge Ricardo Mejía‐Salazar
wiley   +1 more source