Results 191 to 200 of about 7,014,814 (396)

Pharmacologic Interventions in Preventing Ovarian Hyperstimulation Syndrome: A Systematic Review and Network Meta-Analysis [PDF]

, 2016
Junliang Guo, Duoduo Zhang, Yue Zhao, Dan Zhang, Ximeng Zhang, Canquan Zhou, Shuzhong Yao   +6 more
openalex   +1 more source

A Targeted Redox‐Active Dual‐Action Pt(IV)‐Mn(II) Prodrug Displays Enhanced In Vivo Anticancer Activity

Advanced Healthcare Materials, EarlyView.
A new oxaliplatin‐based Pt(IV) prodrug bearing a Mn(II) superoxide dismutase mimic is synthesized and studied, in vitro and in vivo, in the context of colorectal cancer. Encapsulation of this prodrug in an easy‐to‐implement PEGylated micelle formulation demonstrated the highest in vivo anticancer activity among all the tested conditions, supporting the
Alvaro Lopez‐Sanchez, Henri Chédotal, Ram Pravin Kumar Muthuramalingam, Marine Thomas, Jia Ning Nicolette Yau, Priya Ranjan Sahoo, Clotilde Policar, Frédéric Batteux, Kadda Medjoubi, Andrea Somogyi, Giulia Adriani, Carole Nicco, Romain Coriat, Giorgia Pastorin, Hélène C. Bertrand   +14 more
wiley   +1 more source

Mechanisms underlying the therapeutic effects of Qingfeiyin in treating acute lung injury based on GEO datasets, network pharmacology and molecular docking

Comput. Biol. Medicine, 2022
Ying Wang, Yuan Yuan, Wenting Wang, Ying He, H. Zhong, Xiaoxia Zhou, Yong Chen, Xin Cai, Li-qin Liu   +8 more
semanticscholar   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Therapeutic Effects of Qingchang Tongluo Decoction on Intestinal Fibrosis in Crohn’s Disease: Network Pharmacology, Molecular Docking and Experiment Validation

Drug Design, Development and Therapy
Yanan Li,1,2,* Jingyi Hu,1,2,* Ryan Au,1– 3 Cheng Cheng,1,2 Feng Xu,1,2 Weiyang Li,1,2 Yuguang Wu,1,2 Yuan Cui,1,2 Lei Zhu,1,2 Hong Shen1,2 1Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, People’s Republic of ...
Li Y, Hu J, Au R, Cheng C, Xu F, Li W, Wu Y, Cui Y, Zhu L, Shen H   +9 more
doaj  

Effect of Renal Impairment on the Pharmacokinetics of Memantine

Journal of Pharmacological Sciences, 2012
The effect of renal impairment on the pharmacokinetics of a single oral dose of memantine (10 mg) was determined in Japanese subjects. Subjects were assigned to four groups based on baseline creatinine clearance (CLCR): normal renal function (> 80 mL/min,
Takashi Moritoyo, Tomoko Hasunuma, Kazuhiro Harada, Tomonori Tateishi, Makoto Watanabe, Tsutomu Kotegawa, Masahiro Nagai, Yuji Kumagai, Tomomichi Fujitani, Takahumi Okura, Tomikazu Fukuoka, Kenichi Miyoshi, Bunzo Matsuura, Shinya Furukawa, Tomoe Kobori, Hiroyoko Moritoyo, Noriko Nishikawa, Tomoaki Tsujii, Hirotaka Iwaki, Masahiko Nakamura, Satoshi Makino, Kei Ohnuma, Koichiro Yuji, Megumi Hashimoto, Masaru Takasu, Yutaka Hashizume, Koji You, Tomoko Matsumura, Yuji Tanaka, Nahoko Matsumoto, Junichi Nakamura, Jun Miura, Tadao Akizawa, Kozo Kitazawa, Takanori Shibata, Aki Kuroki, Hirokazu Honda, Masanori Mukai, Kyoichi Ohashi, Takuya Morimoto, Hiromitsu Imai, Toshiaki Okudaira, Fuminori Sato, Junko Imanaga, Katsuhiro Tanaka, Masahiro Nomoto   +45 more
doaj  

Novel network pharmacology methods for drug mechanism of action identification, pre-clinical drug screening and drug repositioning

, 2011
Jianghui Xiong, Jianghui Xiong
openalex   +1 more source

Clinical relevance of cyclic GMP modulators: A translational success story of network pharmacology [PDF]

, 2016
JM Oettrich, VT Dao, Jeroen Frijhoff, PWM Kleikers, Ana I. Casas, Adrian J. Hobbs, Harald Schmidt   +6 more
openalex   +1 more source

Mechanism of Sijunzi Decoction in the treatment of colorectal cancer based on network pharmacology and experimental validation.

Journal of Ethnopharmacology, 2022
Luorui Shang, Yichong Wang, Jinxiao Li, Fangyuan Zhou, Kunmin Xiao, Yuhan Liu, Mengqi Zhang, Shuhan Wang, Shenglan Yang   +8 more
semanticscholar   +1 more source

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

Advanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian   +3 more
wiley   +1 more source