Results 271 to 280 of about 7,244,664 (373)

In Situ Proliferating Peptide Nanoparticle Augments Multi‐Target Intervention of Secondary Brain Damage Following Subarachnoid Hemorrhage

Advanced Science, EarlyView.
This work designs an in situ proliferating peptide nanoparticle as a flexible resolution that modulates the neuro‐glia unit to enable enhanced multi‐target combinational therapy for secondary brain damage following subarachnoid hemorrhage. Abstract Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered ...
Yibin Zhang, Peisen Yao, Fuxiang Chen, Shufa Zheng, Xuegang Niu, Haojie Wang, Yuanxiang Lin, Bin Gao, Dezhi Kang   +8 more
wiley   +1 more source

Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer's disease. [PDF]

Sci Rep
Gao W, Yang G, Liu X, Hu K, Pan J, Wang X, Zhao Y, Xu Y.   +7 more
europepmc   +1 more source

A Network Pharmacology Approach to Uncover the Potential Mechanism of Yinchensini Decoction

, 2018
Guoming Chen, Chuyao Huang, Yunyun Liu, Tengyu Chen, Ruilan Huang, Miaozhen Liang, Jie Zhang, Hua Xu   +7 more
openalex   +1 more source

From single drug targets to synergistic network pharmacology in ischemic stroke [PDF]

, 2019
Ana I. Casas, Ahmed Hassan, Simon J. Larsen, Vanessa Gómez‐Rangel, Mahmoud H. Elbatreek, Pamela W. M. Kleikers, Emre Güney, Javier Egea, Manuela G. López, Jan Baumbach, Harald Schmidt   +10 more
openalex   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Revealing Lingonberry's Neuroprotective Potential in Alzheimer's Disease Through Network Pharmacology and Molecular Docking. [PDF]

Int J Mol Sci
Li J, Wang M, Wang Y, Peng X, Lv G, Zheng T, Peng Y, Li J.   +7 more
europepmc   +1 more source

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

Anti-Inflammatory Mechanism Prediction of Sinomenine Based on Network Pharmacology and Its Biological Activity Verification. [PDF]

Biology (Basel)
Song D, Khan A, Dong MH, Lei CW, Feng TT, Zhou Y, Wei X.   +6 more
europepmc   +1 more source

DiffMC‐Gen: A Dual Denoising Diffusion Model for Multi‐Conditional Molecular Generation

Advanced Science, EarlyView.
DiffMC‐Gen, a dual‐diffusion model for 2D and 3D molecular generation, simultaneously optimizes multiple key objectives across the drug design process, enabling the generation of novel, target‐specific small‐molecule ligands with high therapeutic potential.
Yuwei Yang, Shukai Gu, Bo Liu, Xiaoqing Gong, Ruiqiang Lu, Jiayue Qiu, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Exploring the anti-inflammatory activity of fupenzic acid using network pharmacology and experimental validation. [PDF]

Sci Rep
Boukerouis D, Cuadrado I, Benaida ND, Estévez-Braun A, de Las Heras B, Amesty A, Hortelano S.   +6 more
europepmc   +1 more source