Results 271 to 280 of about 7,014,814 (396)

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Investigating the Therapeutic Mechanisms of Honeysuckle (China) in Sepsis Through Network Pharmacology and Experimental Validation. [PDF]

Infect Drug Resist
Liu P, Zeng L, Fu H, Li F.
europepmc   +1 more source

Network Pharmacology Analysis of Traditional Chinese Medicine Formula Xiao Ke Yin Shui Treating Type 2 Diabetes Mellitus [PDF]

, 2019
Jiewen Zhou, Qiuyan Wang, Zhi-Nan Xiang, Qilin Tong, Jun Pan, Luo-Sheng Wan, Jiachun Chen   +6 more
openalex   +1 more source

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, EarlyView.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

Trends and Pitfalls in the Progress of Network Pharmacology Research on Natural Products. [PDF]

Pharmaceuticals (Basel)
Panossian A.
europepmc   +1 more source

Network pharmacology: An approach to the analysis of complex systems underlying traditional chinese medicine

, 2018
Shao Li, Hu Y
openalex   +1 more source

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

Advanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu   +16 more
wiley   +1 more source

Network Pharmacology as a Tool to Investigate the Antioxidant and Anti-Inflammatory Potential of Plant Secondary Metabolites-A Review and Perspectives. [PDF]

Int J Mol Sci
Merecz-Sadowska A, Sadowski A, Zielińska-Bliźniewska H, Zajdel K, Zajdel R.   +4 more
europepmc   +1 more source

A network pharmacology approach to decipher the mechanisms of anti-depression of Xiaoyaosan formula

, 2018
Xuemei Qin, Yao Gao, Li Gao, Junsheng Tian, Xiang Zhang   +4 more
openalex   +1 more source

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source