Results 291 to 300 of about 628,285 (376)

A Knowledge‐Guided Graph Learning Approach Bridging Phenotype‐ and Target‐Based Drug Discovery

Advanced Science, Volume 12, Issue 16, April 24, 2025.
Knowledge‐Guided Drug Relational Predictor (KGDRP), a graph representation learning approach, effectively integrates multiple omics data, including biological network data, gene expression data, and sequence data that incorporates chemical molecular structures.
Qing Ye, Yundian Zeng, Linlong Jiang, Yu Kang, Peichen Pan, Jiming Chen, Yafeng Deng, Haitao Zhao, Shibo He, Tingjun Hou, Chang‐Yu Hsieh   +10 more
wiley   +1 more source

Network pharmacology unveils the intricate molecular landscape of Chrysin in breast cancer therapeutics. [PDF]

Discov Oncol
Ma J, Liu P, Pan L.
europepmc   +1 more source

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming

Advanced Science, EarlyView.
Spatially resolved multiomics reveals that high‐copper zones are closely associated with tumor metastasis, immune‐desert phenotypes, and oxidative‐phosphorylation (OXPHOS)‐dependent proliferation. A targeted bacterial nanovesicle delivering copper‐depleting agents effectively reduces tumor copper levels, inhibits OXPHOS‐dependent tumor growth, and ...
Lin Chen, Saibo Ma, Hao Wu, Lingna Zheng, Yunpeng Yi, Guangnian Liu, Baoyi Li, Jiayi Sun, Yang Du, Bing Wang, Yike Liu, Cheng Zhang, Jing Chang, Yuheng Pang, Wenjing Wang, Meng Wang, Motao Zhu   +16 more
wiley   +1 more source

Network pharmacology analysis of Lanatoside C: molecular targets and mechanisms in the treatment of ulcerative colitis. [PDF]

Front Mol Biosci
Zhu W, Zhang Z, Wang X.
europepmc   +1 more source

Improvements of spontaneous electrical activities of human induced pluripotent stem cell-derived neuronal networks, which can serve as an alternative method to study neurotoxic and pharmacological effects in vitro

, 2018
Laura Nimtz, Maxi Hofrichter, Yaschar Kabiri, Stephan Theiss, James Adjaye, Ellen Fritsche   +5 more
openalex   +1 more source

Osteoblast‐Derived Mitochondria Formulated with Cationic Liposome Guide Mesenchymal Stem Cells into Osteogenic Differentiation

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This study demonstrates that the transfer of mitochondria from osteoblasts to mesenchymal stem cells (MSCs) enhances osteogenic differentiation. MSCs receiving osteoblast‐derived mitochondria exhibit increased expression of key osteogenic markers (Runt‐related transcription factor 2, RUNX2; Osterix, OSX; Osteopontin, OPN) and activate the BMP2 (Bone ...
Hye‐Ryoung Kim, Seonjeong Woo, Hui Bang Cho, Sujeong Lee, Chae Won Cho, Ji‐In Park, Seulki Youn, Gyuwon So, Sumin Kang, Sohyun Hwang, Hye Jin Kim, Keun‐Hong Park   +11 more
wiley   +1 more source

Significance, feasibility, and perspectives of network pharmacology in treating cancer

, 2018
Yuyu Feng
openalex   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Network pharmacology and experimental validation reveal dexmedetomidine's protective mechanisms against acute liver injury in mice. [PDF]

Sci Rep
Zhang C, Fan Y, Qin Z, Su M, Yao F.
europepmc   +1 more source

Network Pharmacology as an Appropriate Bioinformatics Tool for Drug Discovery

, 2018
SN Venugopalan Nair
openalex   +1 more source