Results 301 to 310 of about 7,014,814 (396)

Significance, feasibility, and perspectives of network pharmacology in treating cancer

, 2018
Yuyu Feng
openalex   +1 more source

ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7

Advanced Science, EarlyView.
Histone lysine crotonylation (Kcr) is a highly conserved posttranslational modification implicated with crucial biological processes. This study reveals that ACSS2‐mediated H4K12cr upregulated CLDN7 transcription to strengthen intestinal epithelial barrier.
Ming Yuan, Shaopeng Chen, Zhensen Lin, Runfeng Yu, Kang Chao, Shubiao Ye, Qing Li, Haoxian Ke, Chi Zhang, Junfeng Huang, Guanzhan Liang, Tuo Hu, Xiang Gao, Ping Lan, Xianrui Wu   +14 more
wiley   +1 more source

Mechanism of Ginsenosides in the Treatment of Diabetes Mellitus Based on Network Pharmacology and Molecular Docking. [PDF]

Int J Mol Sci
Huang S, Li F, Xue D, Shi X, Fang X, Li J, Fu Y, Zhao Y, Jin D.   +8 more
europepmc   +1 more source

Network Pharmacology as an Appropriate Bioinformatics Tool for Drug Discovery

, 2018
SN Venugopalan Nair
openalex   +1 more source

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang, Haoyun Li, Hongfei Wang, Liangyu Shi, Ying Shing Chan, Yu Wang, Graham Ka Hon Shea   +6 more
wiley   +1 more source

Erchen Decoction Offers Health Benefits in Regulating Obesity: Component Analysis, Network Pharmacology, and Experiment Verification. [PDF]

Food Sci Nutr
Zhang L, Liu X, Xu M, Liu Y, Yang J, Wang W, Qu H, Guan T, Chen D, Gu R.   +9 more
europepmc   +1 more source

Additional file 1: of Network pharmacology-based strategy to investigate pharmacological mechanisms of Zuojinwan for treatment of gastritis

, 2018
Guohua Yu, Wubin Wang, Xu Wang, Meng Xu, Lili Zhang, Lei Ding, Rui Guo, Yuanyuan Shi   +7 more
openalex   +2 more sources

Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer

Advanced Science, EarlyView.
Single‐cell RNA sequencing of lymph node (LN) samples is performed, and a comprehensive landscape of the entire ecosystem is generated. Paracrine orchestration of TME remodeling induced by GLO1 potentiates LN metastasis in breast cancer. This study offers novel perspectives on the microenvironment remodeling of breast cancer LN metastases, suggesting ...
Jindong Xie, Wenjian Liu, Xinpei Deng, Huan Wang, Xueqi Ou, Xin An, Min‐Yi Situ, Anli Yang, Chuan Peng, Rongfang He, Yi Xie, Hailin Tang, Yuman Chen, Jie‐Ying Liang, Ruonan Shao, Weikai Xiao, Shaoquan Zheng   +16 more
wiley   +1 more source

Integrated network pharmacology reveals the mechanism of action of Xianlinggubao prescription for inflammation in osteoarthritis. [PDF]

BMC Complement Med Ther
Hou J, Li Y, Zhang Y, Yang N, Chen B, Ma G, Zhu N.   +6 more
europepmc   +1 more source

Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis

, 2019
Yueying Tao, Kunming Tian, Ji Chen, Danfeng Tan, Yan Liu, Yongai Xiong, Zehui Chen, Yingbiao Tian   +7 more
openalex   +1 more source