Results 311 to 320 of about 628,285 (376)

Exploring the beneficial effect of gut microbiota metabolites on diabetic nephropathy via network pharmacology study. [PDF]

Sci Rep
Yao W, Huo J, Liu K, Tao P.
europepmc   +1 more source

Genetics‐Based Targeting Strategies for Precise Neuromodulation

Advanced Science, EarlyView.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He, Zhidong Wei, Jianda Xu, Fei Jin, Tong Li, Lili Qian, Juan Ma, Weiying Zheng, Negar Javanmardi, Ting Wang, Kangjian Sun, Zhang‐Qi Feng   +11 more
wiley   +1 more source

The mechanistic study of codonopsis pilosula on laryngeal squamous cell carcinoma based on network pharmacology and experimental validation. [PDF]

Front Pharmacol
Guo H, Lou Y, Hou X, Guan X, Guo Y, Han Q, Xue X, Wang Y, He L, Li Z, Zhang C.   +10 more
europepmc   +1 more source

Pupylation‐Based Proximity Labeling Unravels a Comprehensive Protein and Phosphoprotein Interactome of the Arabidopsis TOR Complex

Advanced Science, EarlyView.
The target of rapamycin (TOR) complex is a central plant growth regulator. Here, the protein–protein interactions underlying its various functions are mapped by pupylation‐based proximity‐labeling in Arabidopsis, using TOR complex subunits LST8‐1 and RAPTOR1, alongside TOR inhibitor FK506‐binding protein, as baits.
Shuai Zheng, Leonard Blaschek, Delphine Pottier, Luuk Robin Hoegen Dijkhof, Beyza Özmen, Peng Ken Lim, Qiao Wen Tan, Marek Mutwil, Alexander Sebastian Hauser, Staffan Persson   +9 more
wiley   +1 more source

FAERS based disproportionality analysis and network pharmacology investigation of taxanes associated drug induced liver injury. [PDF]

Sci Rep
Cheng Y, Yang Y, Su Y, Chen R, Qian D, Xu J.   +5 more
europepmc   +1 more source

Patient‐Derived Bladder Cancer Organoids as a Valuable Tool for Understanding Tumor Biology and Developing Personalized Treatment

Advanced Science, Volume 12, Issue 13, April 3, 2025.
We have established the first Asian‐based bladder cancer PDOs biobank, demonstrating their accuracy in mirroring parental tumors’ properties. Drug screening reveals diverse sensitivities to chemotherapies and targeted therapies, validated by PDO xenografts and patient outcomes. Genetic profiling identifies key genes associated with response to standard
Hongda Zhao, Na Lin, Vincy Wing Sze Ho, Kang Liu, Xuan Chen, Hongwei Wu, Peter Ka‐Fung Chiu, Linda Huang, Zahra Dantes, Ka‐Leung Wong, Ho‐Fai Chau, Ivan Ching‐Ho Ko, Chris Ho‐Ming Wong, David Ka‐Wai Leung, Steffi Kar‐Kei Yuen, Dinglan Wu, Xiaofan Ding, Chi Fai Ng, Jeremy Yuen‐Chun Teoh   +18 more
wiley   +1 more source

Xijiao Dihuang Decoction for Sepsis-Induced Acute Lung Injury: Network Pharmacology and Molecular Dynamics Insights. [PDF]

J Inflamm Res
Xu J, Jiao C, Du H, Guo X, Wang M, Ma Y, Yin Y, Liu M, Shao R.   +8 more
europepmc   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

Integrated network pharmacology, molecular docking, and animal experiments to reveal the potential mechanism of hesperetin on COPD. [PDF]

Sci Rep
Wang J, Wang H, Kang X, Wang X, Li X, Guo J, Jing X, Chu X, Han X.   +8 more
europepmc   +1 more source

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

Advanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai, Ashley Gomm, Chi‐Hyeon Yoo, Prasenjit Mondal, Fleur Marie Lobo, Hui Meng, Yanting Zhou, Weiyao Xie, Hsiao‐Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang, Yu Lan   +12 more
wiley   +1 more source