Results 331 to 340 of about 7,014,814 (396)

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Exploreing the potential mechanism of Aitongxiao formula inhibiting hepatocellular carcinoma in vitro and in vivo based on network Pharmacology. [PDF]

Sci Rep
Zhao X, Zhou H, Xia M, Cheng Q, Wang R, Tao J, Leng J.   +6 more
europepmc   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

Deciphering anti-colorectal cancer potential of Avicennia alba bioactives via network pharmacology and in vitro validation. [PDF]

Sci Rep
Irham LM, Adikusuma W, Illian DN, Mazaya M, Mubaraq A, Ma'ruf M, Rizki NK, Mutia MS, Ali HM, Basyuni M.   +9 more
europepmc   +1 more source

Exploring the Mechanisms of Lijin Fang on Treg/Th17 Cell Imbalance in COPD Based on Network Pharmacology. [PDF]

Int J Chron Obstruct Pulmon Dis
Li ZH, Chen SN, Pan L, Liu R, Liang W, Luo MQ, Liao HF, Feng J, Wang HZ, Huang YG, Zheng JH.   +10 more
europepmc   +1 more source

Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma. [PDF]

Open Med (Wars)
Huang J, Jiang C, Li T, Hu Z, Xiang Q, Chen H.   +5 more
europepmc   +1 more source

Network pharmacology approach to unveiling the mechanism of berberine in the amelioration of morphine tolerance. [PDF]

J Tradit Chin Med
Shuai H, Zhikang D, Zirui W, Tianfeng H, Yali GE, Jianwen S, Ju G.   +6 more
europepmc   +1 more source

Exploration of Liuwei Dihuang Pill on periodontitis based on network pharmacology and molecular docking. [PDF]

Medicine (Baltimore)
Luo Y, Liu C, Liu J, Wang H, Fu Y, Liu Y.   +5 more
europepmc   +1 more source

Network Pharmacology Approaches to Myocardial Infarction Reperfusion Injury: Exploring Mechanisms, Pathophysiology, and Novel Therapies. [PDF]

Biomedicines
Das J, Sah AK, Choudhary RK, Elshaikh RH, Bhui U, Chowdhury S, Abbas AM, Shalabi MG, Siddique NA, Alshammari RR, Trivedi N, Ali Buwaiqi KS, Al Ghenaimi S, Prabhakar PK.   +13 more
europepmc   +1 more source