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Common Network Pharmacology Software
2021As a growing trend in current pharmacology research and an important medical application in network science research, network pharmacology has become an indispensable complement to traditional pharmacology research with the immense accumulation and integration of large-scale pharmacology and disease molecular network data.
Xuezhong Zhou, Ning Wang, Xing Zhai
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Network Pharmacology of Glioblastoma
Current Drug Discovery Technologies, 2013With increasing knowledge of cellular networks of gene and molecular interactions, and their alterations in GBM (glioblastoma multiforme), it is now possible to apply methods of Network Pharmacology (NP) to predict candidate drug targets for this malignant brain tumor.
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Network Pharmacology: Exploring the Resources and Methodologies
Current Topics in Medicinal Chemistry, 2018Multi-target and combinatorial therapies have been focused for the past several decades. These approaches achieved considerable therapeutic efficacy by modulating the activities of the targets in complex diseases such as HIV-1 infection, cancer and diabetes disease.
Arif Ali +6 more
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Network Pharmacology: Reigning in Drug Attrition?
Current Drug Discovery Technologies, 2013In the process of drug development, there has been an exceptionally high attrition rate in oncological compounds entering late phases of testing. This has seen a concurrent reduction in approved NCEs (new chemical entities) reaching patients. Network pharmacology has become a valuable tool in understanding the fine details of drug-target interactions ...
Minjel Shah +3 more
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Platforms and networks in triterpenoid pharmacology
Drug Development Research, 2007AbstractUsing the pentacyclic, naturally occurring triterpenoids, oleanolic, ursolic, and betulinic acids, as starting materials, we have developed a new series of multifunctional drugs for potential clinical use. These agents have anti‐inflammatory, anti‐oxidative, anti‐proliferative, pro‐apoptotic, and differentiating activities.
Gordon W. Gribble +7 more
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Drug Repositioning Through Network Pharmacology
Current Topics in Medicinal Chemistry, 2016Low drug productivity has been a significant problem of the pharmaceutical industry for several decades even though numerous novel technologies were introduced during this period. Currently pharmacologic dogma, "single drug, single target, single disease", is at the root of the lack of drug productivity.
Hao Ye +4 more
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Tools for network pharmacology study: network visualization and network analysis
China Journal of Chinese Materia Medica, 2011Network pharmacology has been one of the academic frontiers of traditional Chinese medicine research. In this paper, we generally showed the work flow of network pharmacology research, and introduced concepts of network visualization and network analysis, as well the commonly-used tools, such as Cytoscape.
Yi Wang, Leihong Wu, Xiaohui Fan
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Network Pharmacology and Epilepsy
2016Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Catedra de Quimica Medicinal; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas.
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Networks and Pathways in Systems Pharmacology
2017This chapter presents an extensive overview of aspects involved in the thriving field of systems pharmacology. The three main directions along which network- and pathway-based analysis methods can contribute in systems pharmacology are spotlighted. Current approaches for the characterization of drugs mechanism of action, including the elucidation of ...
Anastasios Bezerianos +2 more
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Editorial: Network pharmacology and AI
Journal of Ethnopharmacology, 2023Shao, Li +3 more
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