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Transplanting network pharmacology technology into food science research: A comprehensive review on uncovering food-sourced functional factors and their health benefits.

Comprehensive Reviews in Food Science and Food Safety
Network pharmacology is an emerging interdisciplinary research method. The application of network pharmacology to reveal the nutritional effects and mechanisms of active ingredients in food is of great significance in promoting the development of ...
Qing Shen   +13 more
semanticscholar   +1 more source

Network Pharmacology of Glioblastoma

Current Drug Discovery Technologies, 2013
With increasing knowledge of cellular networks of gene and molecular interactions, and their alterations in GBM (glioblastoma multiforme), it is now possible to apply methods of Network Pharmacology (NP) to predict candidate drug targets for this malignant brain tumor.
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Network Pharmacology: Exploring the Resources and Methodologies

Current Topics in Medicinal Chemistry, 2018
Multi-target and combinatorial therapies have been focused for the past several decades. These approaches achieved considerable therapeutic efficacy by modulating the activities of the targets in complex diseases such as HIV-1 infection, cancer and diabetes disease.
Arif Ali   +6 more
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Platforms and networks in triterpenoid pharmacology

Drug Development Research, 2007
AbstractUsing the pentacyclic, naturally occurring triterpenoids, oleanolic, ursolic, and betulinic acids, as starting materials, we have developed a new series of multifunctional drugs for potential clinical use. These agents have anti‐inflammatory, anti‐oxidative, anti‐proliferative, pro‐apoptotic, and differentiating activities.
Gordon W. Gribble   +7 more
openaire   +2 more sources

Network Pharmacology: Reigning in Drug Attrition?

Current Drug Discovery Technologies, 2013
In the process of drug development, there has been an exceptionally high attrition rate in oncological compounds entering late phases of testing. This has seen a concurrent reduction in approved NCEs (new chemical entities) reaching patients. Network pharmacology has become a valuable tool in understanding the fine details of drug-target interactions ...
Minjel Shah   +3 more
openaire   +3 more sources

Drug Repositioning Through Network Pharmacology

Current Topics in Medicinal Chemistry, 2016
Low drug productivity has been a significant problem of the pharmaceutical industry for several decades even though numerous novel technologies were introduced during this period. Currently pharmacologic dogma, "single drug, single target, single disease", is at the root of the lack of drug productivity.
Hao Ye   +4 more
openaire   +3 more sources

Tools for network pharmacology study: network visualization and network analysis

China Journal of Chinese Materia Medica, 2011
Network pharmacology has been one of the academic frontiers of traditional Chinese medicine research. In this paper, we generally showed the work flow of network pharmacology research, and introduced concepts of network visualization and network analysis, as well the commonly-used tools, such as Cytoscape.
Yi Wang, Leihong Wu, Xiaohui Fan
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Network Pharmacology and Epilepsy

2016
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Catedra de Quimica Medicinal; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas.
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Networks and Pathways in Systems Pharmacology

2017
This chapter presents an extensive overview of aspects involved in the thriving field of systems pharmacology. The three main directions along which network- and pathway-based analysis methods can contribute in systems pharmacology are spotlighted. Current approaches for the characterization of drugs mechanism of action, including the elucidation of ...
Anastasios Bezerianos   +2 more
openaire   +2 more sources

Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula.

Journal of Ethnopharmacology, 2023
L. Zhao   +6 more
semanticscholar   +1 more source

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