Results 51 to 60 of about 376,245 (265)

Control network reliability reconstruction for Zatonie dam

Reports on Geodesy and Geoinformatics, 2018
Absolute horizontal displacements are an important element of dam safety level assessment. Appropriate design of measurement network is a prerequisite for the acquisition of displacement values that meet the reliability requirements.
Nowak Edward, Odziemczyk Waldemar
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

MGP: Multi-Stage Grouped Probe Detection for Fault Localization in Vehicle-to-Ground Communication Networks

IEEE Open Journal of Vehicular Technology
The Vehicle-to-Ground (V2G) emergency communication network is a dedicated network established to respond to emergencies, such as natural disasters and traffic accidents, and it plays a crucial role in ensuring the safe and smooth operation of vehicles ...
Wenxiao Wang, Ping Dong, Yuyang Zhang, Wenxuan Qiao, Xiaoya Zhang, Chengxiao Yu, Hongke Zhang   +6 more
doaj   +1 more source

A novel Direct Small World network model

上海师范大学学报. 自然科学版, 2016
There is a certain degree of redundancy and low efficiency of existing computer networks.This paper presents a novel Direct Small World network model in order to optimize networks.In this model,several nodes construct a regular network.Then,randomly ...
LIN Tao, GAO Jianhua, FU Xue, MA Yan, LIN Yan   +4 more
doaj   +1 more source

A Stable and Reliable Short-Path Routing Scheme for Efficient Acoustic Wireless Sensor Networks (AWSNs)

IEEE Access, 2020
Owning to the vital resources in a harsh and unforeseeable aqueous environment, the network stability and reliability in underwater acoustic wireless sensor networks (UAWSNs) have paramount significance. Stability guarantees the consistent performance of
Ubaid Ullah, Ali Raza Shahid, Muhammad Irfan, Junaid Qadir, Mehmood Nawaz, Rizwan Qureshi   +5 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

BiLSTM-Based Fault Anticipation for Predictive Activation of FRER in Time-Sensitive Industrial Networks

IoT
Frame Replication and Elimination for Reliability (FRER) in Time-Sensitive Networking (TSN) enhances fault tolerance by duplicating critical traffic across disjoint paths.
Mohamed Seliem, Utz Roedig, Cormac Sreenan, Dirk Pesch   +3 more
doaj   +1 more source