Results 211 to 220 of about 574,210 (309)

High accuracy capillary network representation in digital rock reveals permeability scaling functions. [PDF]

Sci Rep, 2021
Neumann RF, Barsi-Andreeta M, Lucas-Oliveira E, Barbalho H, Trevizan WA, Bonagamba TJ, Steiner MB.   +6 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A multi-source molecular network representation model for protein-protein interactions prediction. [PDF]

Sci Rep
Zou HT, Ji BY, Xie XL.
europepmc   +1 more source

Ancestral sequences of a large promiscuous enzyme family correspond to bridges in sequence space in a network representation. [PDF]

J R Soc Interface, 2021
Buchholz PCF, van Loo B, Eenink BDG, Bornberg-Bauer E, Pleiss J.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

WAFNRLTG: A Novel Model for Predicting LncRNA Target Genes Based on Weighted Average Fusion Network Representation Learning Method. [PDF]

Front Cell Dev Biol, 2021
Li J, Yang Z, Wang D, Li Z.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Network representation of multicellular activity in pancreatic islets: Technical considerations for functional connectivity analysis. [PDF]

PLoS Comput Biol
Šterk M, Zhang Y, Pohorec V, Leitgeb EP, Dolenšek J, Benninger RKP, Stožer A, Kravets V, Gosak M.   +8 more
europepmc   +1 more source

A Resource for the Network Representation of Cell Perturbations Caused by SARS-CoV-2 Infection. [PDF]

Genes (Basel), 2021
Perfetto L, Micarelli E, Iannuccelli M, Lo Surdo P, Giuliani G, Latini S, Pugliese GM, Massacci G, Vumbaca S, Riccio F, Fuoco C, Paoluzi S, Castagnoli L, Cesareni G, Licata L, Sacco F.   +15 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source