Results 51 to 60 of about 179,792,601 (285)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Resource-Efficiently Survivable IoT Services Provisioning via Virtual Network Embedding in Fiber-Wireless Access Network

IEEE Access, 2019
Fiber-Wireless (FiWi) access network is a promising network architecture to provide the constantly available connections for the collaboration of objects in the Internet of Things (IoT). The network virtualization is dominating the evolution of FiWi, i.e.
Yejun Liu, Pengchao Han, Jian Hou, Jianbo Zheng   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Insights from tracking white-bellied pangolins, and implications for telemetry-based research on Phataginus species

Oryx
Pangolins are one of the least studied mammal groups, with major gaps in our knowledge of their population status and ranging behaviour. These shortfalls arise from their elusive habits and the lack of telemetry devices suited to their biology and ...
Charles A. Emogor, Francis Muyorkem Akor, Benedict Ashindobe Atsu, Omini Iferi Bassey, Frederick Mkpe Bassey, John Osang Bisong, Alasdair Davies, Isa Bassey Ebri, Edet Etim Ekpo, Roland Kays, Michael Noonan, Shadrach Dominic Ogar, Andrew Balmford   +12 more
doaj   +1 more source

Analysis of Human Resource Allocation Model for Tourism Industry Based on Improved BP Neural Network

Journal of Mathematics, 2022
This paper analyzes the deficiencies of human resource allocation in the tourism industry by investigating the human resource allocation in the tourism industry, puts forward corresponding improvement measures and suggestions, and strives to provide ...
Shuo Zhu, Yan Liu
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Catholic Women's Network, September / October, 1992

, 1992
Digitized version of a newspaper published by the Catholic Women's Network (CWN), a non-profit educational organization for women's spirituality and personal growth.
Catholic Women's Network (Sunnyvale, Calif);
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Predictive Network Slicing Resource Orchestration: A VNF Approach

Future Internet
As network slicing gains traction in cloud computing environments, efficient management and orchestration systems are required to realize the benefits of this technology.
Andrés Cárdenas, Luis Sigcha, Mohammadreza Mosahebfard   +2 more
doaj   +1 more source