Results 241 to 250 of about 127,993 (305)

Automated deep-learning quantification of nine patellofemoral instability parameters on multislice CT images : development and validation of the GU2Net model. [PDF]

Bone Jt Open
Ye Q, Ying Y, Hua J, Ye J, Zhu C, Zheng B.   +5 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Multi-label Ensemble Model for Knee Joint Anatomy and Lesion Segmentation: Segmentation of Clinical Images With Ensembling, Morphology, and Attention (SCEMA). [PDF]

Magn Reson Med
Yu AS, Yang M, Nakamura K, Lartey R, Tosun S, Subhas N, Winalski C, Chaudhary V, Li X.   +8 more
europepmc   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Histology-informed spatial domain identification through multi-view graph convolutional networks. [PDF]

PLoS Comput Biol
Zhang H, Chang J, Li Z, Sun Y, Hu P, Wang H, Yang H, Ren Y, Zhang X, Chen Z, Wong KW, Shao H.   +11 more
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

A Multi-Dimensional Vision-Based System for External Thread Defect Detection with Integrated Security Defense. [PDF]

Sensors (Basel)
Li L, Zhang G.
europepmc   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Leveraging Spot-Gene Heterogeneous Graphs for Unified Spatially Resolved Transcriptomics Domain Detection on Single-Slice and Multi-Slice Data. [PDF]

Genes (Basel)
Xia L, Ding Z, Zhang X, Qian K, Li H.
europepmc   +1 more source

vEMRec: High-Resolution Volume Electron Microscopy Reconstruction Based on Structure-Preserving and High-Fidelity 3D Alignment. [PDF]

Adv Sci (Weinh)
Zhang Z, Li H, Yang Z, Xu Z, Sun D, Gao X, Zhang F, Han R.   +7 more
europepmc   +1 more source